Mefeclorazine

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Names

[ Name ]:
Mefeclorazine

[Synonym ]:
1-(2-chloro-phenyl)-4-(3,4-dimethoxy-phenethyl)-piperazine
Mefeclorazina [INN-Spanish]
4-<2-Chlor-phenyl>-1-<3,4-dimethoxy-phenethyl>-piperazin
1-o-Chlorophenyl-4-(3,4-dimethoxyphenethyl)piperazine
Mefeclorazinum [INN-Latin]
1-(2-Chlorphenyl)-4-(3,4-dimethoxyphenethyl)piperazine
N-(Dimethoxy-3,4-phenethyl),-N'-(chloro-2-phenyl) piperazine
Piperazine,1-(o-chlorophenyl)-4-(3,4-dimethoxyphenethyl)
Mefeclorazine
SD 218-06
Mepheclorazin

Chemical & Physical Properties

[ Density]:
1.16g/cm3

[ Boiling Point ]:
490.1ºC at 760 mmHg

[ Molecular Formula ]:
C₂₀H₂₅ClN₂O₂

[ Molecular Weight ]:
360.87800

[ Flash Point ]:
250.2ºC

[ Exact Mass ]:
360.16000

[ PSA ]:
24.94000

[ LogP ]:
3.72480

[ Vapour Pressure ]:
9.43E-10mmHg at 25°C

[ Index of Refraction ]:
1.57

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TL2803000

CHEMICAL NAME :: Piperazine, 1-(o-chlorophenyl)-4-(3,4-dimethoxyphenethyl)-

CAS REGISTRY NUMBER :: 1243-33-0

BEILSTEIN REFERENCE NO. :: 0627902

LAST UPDATED :: 199612

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C20-H25-Cl-N2-O2

MOLECULAR WEIGHT :: 360.92

WISWESSER LINE NOTATION :: T6N DNTJ A2R CO1 DO1& DR CG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PSCBAY Psychopharmacology Service Center, Bulletin. (Bethesda, MD) V.1-3, 1961-65. For publisher information, see PSYBB9. Volume(issue)/page/year: 2,17,1963

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Autonomic Nervous System - central sympatholytic Vascular - BP elevation not characterized in autonomic section Lungs, Thorax, or Respiration - bronchiolar dilation

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 8,104,1965

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 55 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 133,29,1961

Safety Information

[ HS Code ]:
2933599090

Customs

[ HS Code ]: 2933599090

[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

3-[(4-Bromo-3-methylphenyl)thio]-5-tert-butyl-6-hydroxy-2-methylbenzoic acid
N-(4-(4-Bromophenyl)thiazol-2-yl)-2-(methylthio)-N-((tetrahydrofuran-2-yl)methyl)nicotinamide
2,3-Dihydro-7-methyl-6-nitroindole
ethyl 2-(2-(5-ethoxy-6-ethyl-1-methyl-2,4-dioxo-1,2-dihydropyrido[2,3-d]pyrimidin-3(4H)-yl)acetamido)benzoate
ethyl 4-{[(5-ethoxy-6-ethyl-1-methyl-2,4-dioxo-1,4-dihydropyrido[2,3-d]pyrimidin-3(2H)-yl)acetyl]amino}benzoate
methyl 4-(2-(5-ethoxy-6-ethyl-1-methyl-2,4-dioxo-1,2-dihydropyrido[2,3-d]pyrimidin-3(4H)-yl)acetamido)benzoate
N-(4-acetylphenyl)-2-(5-ethoxy-6-ethyl-1-methyl-2,4-dioxo-1,2-dihydropyrido[2,3-d]pyrimidin-3(4H)-yl)acetamide
N-(3-acetamidophenyl)-2-(5-ethoxy-6-ethyl-1-methyl-2,4-dioxo-1,2-dihydropyrido[2,3-d]pyrimidin-3(4H)-yl)acetamide
4-Methoxy-6-[(4-methylthio-phenyl)-thio]-benzoic acid
2-(2-((4-fluorobenzyl)thio)-5-(hydroxymethyl)-1H-imidazol-1-yl)-N-(2-methoxyethyl)acetamide

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