6-aminocarbovir

Names

[ CAS No. ]:
124752-25-6

[ Name ]:
6-aminocarbovir

[Synonym ]:
ABACAVIR RELATED COMPOUND
Descyclopropyl Abacavir
Abacavir Impurity 3

Chemical & Physical Properties

[ Melting Point ]:
180-182°C

[ Molecular Formula ]:
C11H14N6O

[ Molecular Weight ]:
246.26800

[ Exact Mass ]:
246.12300

[ PSA ]:
115.87000

[ LogP ]:
1.26260

[ Vapour Pressure ]:
1.21E-16mmHg at 25°C

[ Storage condition ]:
-20?C Freezer

Safety Information

[ Symbol ]:

GHS05

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H318

[ Precautionary Statements ]:
P280-P305 + P351 + P338

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
41-43

[ Safety Phrases ]:
26-36/37-39

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • ((1S,4R)-4-(2,6-dichloro-9H-purin-9-yl)cyclopent-2-en-1-yl)methanol
  • 9-[cis-(1'R,4'S)-4'-acetoxymethyl-2'-cyclopenten-1'-yl]-9H-2-amino-6-chloropurine
  • (-)-carbovir

DownStream

Articles

Comparative brain exposure to (-)-carbovir after (-)-carbovir or (-)-6-aminocarbovir intravenous infusion in rats.

Pharm. Res. 12(6) , 911-5, (1995)

Evaluate the ability of (-)-6-aminocarbovir ((-)-6AC) to improve the CNS exposure to (-)-carbovir ((-)-CBV).Activation of (-)-6AC in vitro was assessed by incubations of rat brain tissue homogenates. ...

Pharmacokinetic evaluation of (-)-6-aminocarbovir as a prodrug for (-)-carbovir in rats.

Drug Metab. Dispos. 20(1) , 47-51, (1992)

The recently synthesized carbocyclic 2',3'-didehydro-2',3'-dideoxy-6-deoxy-6-amino-guanosine [(-)6AC] was evaluated as a prodrug for carbovir, carbocyclic 2',3'-didehydro-2',3'-dideoxyguanosine [(-)CB...

First-pass disposition of (-)-6-aminocarbovir in rats. I. Prodrug activation may be limited by access to enzyme.

Drug Metab. Dispos. 27(1) , 113-21, (1999)

Several in vitro and in situ approaches were used to determine the dominant presystemic activation site for (-)-6-aminocarbovir, (-)-carbocyclic 2',3'-didehydro-2', 3'-dideoxy-6-deoxy-6-aminoguanosine...


More Articles

Related Compounds

  • 6-(17,19-Dimethylhenicosyl)tetrahydro-2H-pyran-2-dodecanoic acid methyl ester
  • 6-methoxyaromadendrin 3-O-acetate
  • 6,6,6-trifluoro-5-hydroxy-2,2-dimethyl-5-(trifluoromethyl)hexan-3-one
  • 6-methyl-1,3-thiazinane-2-thione
  • 6-chloro-3-[(dimethylamino)methyl]-3H-2-benzothiophen-1-one,hydrochloride
  • 6-(4-T-BUTYLPHENYL)-6-OXOHEXANOIC ACID
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • tert-Butyl-DL-alanine
  • 4-amino-N-[2-tert-butyl-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-5-yl]-N-ethylbenzenesulfonamide
  • N-[3-(Aminooxy)propyl]-N-butyl-1-butanamine