l-DROMORAN TARTRATE

Names

[ CAS No. ]:
125-72-4

[ Name ]:
l-DROMORAN TARTRATE

[Synonym ]:
Lemoran
Levorphanol tartrate
EINECS 204-753-8
Ro-1-5431/7
17-methyl-morphinan-3-ol,Lg-hydrogentartrate
levorphanol hydrogen tartrate
Levo-Dromoran
LEVORPHANOL TARTRATE NARCOTIC ANALGESIC
Levorphan tartrate
Levo-dromoran tartrate
17-Methyl-morphinan-3-ol,Lg-Hydrogentartrat
D-(-)-Levorphanol tartrate
L-3-Hydroxy-N-methylmorphinan bitartrate
Levorphanol bitartrate

Chemical & Physical Properties

[ Boiling Point ]:
759ºC at 760mmHg

[ Molecular Formula ]:
C21H29NO7

[ Molecular Weight ]:
407.45700

[ Flash Point ]:
412.8ºC

[ Exact Mass ]:
407.19400

[ PSA ]:
138.53000

[ LogP ]:
0.89570

[ Vapour Pressure ]:
1.19E-17mmHg at 25°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
QD1925000
CAS REGISTRY NUMBER :
125-72-4
LAST UPDATED :
199504
DATA ITEMS CITED :
14
MOLECULAR FORMULA :
C17-H23-N-O.C4-H6-O6
MOLECULAR WEIGHT :
407.51
WISWESSER LINE NOTATION :
T6 G666/FQ 2AF Q FX ONT&TTJ IQ O -L &622 QVYQYQVQ &621

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
46 mg/kg
TOXIC EFFECTS :
Behavioral - analgesia
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
150 mg/kg
TOXIC EFFECTS :
Behavioral - tremor Behavioral - rigidity (including catalepsy) Kidney, Ureter, Bladder - urine volume increased
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
48 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Behavioral - rigidity (including catalepsy)
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
110 mg/kg
TOXIC EFFECTS :
Behavioral - tremor Behavioral - rigidity (including catalepsy) Kidney, Ureter, Bladder - urine volume increased
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
27 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
285 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
92 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - other changes
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
187 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
32 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Parenteral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
14723 ug/kg
TOXIC EFFECTS :
Behavioral - analgesia
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
20 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
25 mg/kg
SEX/DURATION :
female 9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)

MUTATION DATA

TEST SYSTEM :
Rodent - rat
DOSE/DURATION :
2500 ug/kg
REFERENCE :
RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD Pub. Ltd., P.O. Box 966, Westbury, NY 11590) V.1- 1970- Volume(issue)/page/year: 3,105,1972 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X6071 No. of Facilities: 23 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 4165 (estimated) No. of Female Employees: 3802 (estimated)

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Tartaric acid
  • levorphanol

DownStream

  • levorphanol
  • l-3-hydroxy-n-methylmorphinan dihydrate

Related Compounds

  • DIMETHYL L-TARTRATE CYCLIC SULFATE
  • dimethyl-l-tartrate
  • Lorcaserin-L-tartrate (2:1)
  • Furaltadone L-tartrate
  • Gemigliptin L-tartrate Sesquihydrate
  • 6-[2-[4-[bis(4-fluorophenyl)methylidene]piperidin-1-yl]ethyl]-7-methyl-[1,3]thiazolo[3,2-a]pyrimidin-5-one,(2R,3R)-2,3-dihydroxybutanedioic acid
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 2-{1-[1-(cyclopropylmethyl)-1H-1,2,3-triazol-4-yl]cyclopropyl}ethan-1-amine
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • N,N-dimethyl-4-[2-(methylamino)acetyl]benzamide
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 4-[(2-Hydroxy-3-methoxyphenyl)methyl]piperidin-4-ol
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde