Aminoglutethimide
Suppliers
Names
[ CAS No. ]:
125-84-8
[ Name ]:
Aminoglutethimide
[Synonym ]:
Orimeten
UNII:0O54ZQ14I9
3-(p-Aminophenyl)-3-ethylpiperidine-2,6-dione (3-(4-Aminophenyl)-3-ethyl-2,6-piperidinedione
Cytadren
(RS)-Aminoglutethimide
2,6-Piperidinedione, 3-(4-aminophenyl)-3-ethyl-
MFCD00010122
EINECS 204-756-4
(±)-Aminoglutethimide
(±)-p-Aminoglutethimide
2,6-Piperidinedione, 3-(4-aminophenyl)-3-ethyl-, (+)-
aminoglutethimide
DL-Aminoglutethimide
3-(4-aminophenyl)-3-ethylpiperidine-2,6-dione
p-Aminoglutethimide
3-(4-Aminophenyl)-3-ethyl-2,6-piperidinedione
3-(p-Aminophenyl)-3-ethylpiperidine-2,6-dione 3-(4-Aminophenyl)-3-ethyl-2,6-piperidinedione
Chemical & Physical Properties
[ Density]:
1.2±0.1 g/cm3
[ Boiling Point ]:
457.4±45.0 °C at 760 mmHg
[ Melting Point ]:
152-154 °C(lit.)
[ Molecular Formula ]:
C13H16N2O2
[ Molecular Weight ]:
232.278
[ Flash Point ]:
230.4±28.7 °C
[ Exact Mass ]:
232.121185
[ PSA ]:
72.19000
[ LogP ]:
1.41
[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C
[ Index of Refraction ]:
1.566
[ Water Solubility ]:
H2O: 0.2 mg/mL, slightly soluble
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- MA4026950
- CHEMICAL NAME :
- Glutarimide, 2-(p-aminophenyl)-2-ethyl-
- CAS REGISTRY NUMBER :
- 125-84-8
- BEILSTEIN REFERENCE NO. :
- 0210656
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 5
- MOLECULAR FORMULA :
- C13-H16-N2-O2
- MOLECULAR WEIGHT :
- 232.31
- WISWESSER LINE NOTATION :
- T6VMVTJ D2 DR DZ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 20500 mg/kg/94W-I
- TOXIC EFFECTS :
- Blood - agranulocytosis
- REFERENCE :
- BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year: 291,970,1985
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 21 mg/kg/3D-I
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - body temperature increase
- REFERENCE :
- AIMEAS Annals of Internal Medicine. (American College of Physicians, 4200 Pine St., Philadelphia, PA 19104) V.1- 1927- Volume(issue)/page/year: 105,633,1986
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 625 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - antipsychotic
- REFERENCE :
- JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 18,736,1975 ** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 3630 mg/kg
- SEX/DURATION :
- female 1-35 week(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - urogenital system
- REFERENCE :
- AJDCAI American Journal of Diseases of Children. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1-80(3), 1911-50; V.100- 1960- Volume(issue)/page/year: 124,421,1972 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5423 No. of Facilities: 18 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 403 (estimated) No. of Female Employees: 179 (estimated)
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H315-H319-H335
[ Precautionary Statements ]:
P305 + P351 + P338
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves
[ Hazard Codes ]:
Xi:Irritant;
[ Risk Phrases ]:
R36/37/38
[ Safety Phrases ]:
S26-S36
[ RIDADR ]:
3249
[ WGK Germany ]:
3
[ RTECS ]:
MA4026950
[ Packaging Group ]:
III
[ Hazard Class ]:
6.1(b)
[ HS Code ]:
2925190090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2925190090
[ Summary ]:
2925190090 other imides and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%
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