Cefixime trihydrate

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Names

[ Name ]:
Cefixime trihydrate

[Synonym ]:
(6R,7R)-7-({(2Z)-2-(2-Amino-1,3-thiazol-4-yl)-2-[(carboxymethoxy)imino]acetyl}amino)-8-oxo-3-vinyl-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid trihydrate
CEFIXIME TRIHYDRATE
5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-[(carboxymethoxy)imino]-1-oxoethyl]amino]-3-ethenyl-8-oxo-, (6R,7R)-, hydrate (1:3)

Chemical & Physical Properties

[ Melting Point ]:
218-225℃

[ Molecular Formula ]:
C₁₆H₂₁N₅O₁₀S₂

[ Molecular Weight ]:
507.495

[ Exact Mass ]:
507.072968

[ PSA ]:
265.74000

[ LogP ]:
0.17230

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H317-H334

[ Precautionary Statements ]:
P261-P280-P342 + P311

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
R42/43

[ Safety Phrases ]:
S22

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Articles

In vitro antibacterial activity of AZD0914, a new spiropyrimidinetrione DNA gyrase/topoisomerase inhibitor with potent activity against Gram-positive, fastidious Gram-Negative, and atypical bacteria.

Antimicrob. Agents Chemother. 59(1) , 467-74, (2014)

AZD0914 is a new spiropyrimidinetrione bacterial DNA gyrase/topoisomerase inhibitor with potent in vitro antibacterial activity against key Gram-positive (Staphylococcus aureus, Staphylococcus epiderm...

Characterization of urinary tract infection-associated Shiga toxin-producing Escherichia coli.

Infect. Immun. 82(11) , 4631-42, (2014)

Enterohemorrhagic Escherichia coli (EHEC), a subgroup of Shiga toxin (Stx)-producing E. coli (STEC), is a leading cause of diarrhea and hemolytic-uremic syndrome (HUS) in humans. However, urinary trac...

The characterization and antibiotic resistance profiles of clinical Escherichia coli O25b-B2-ST131 isolates in Kuwait.

BMC Microbiol. 14 , 214, (2014)

Escherichia coli O25b-B2-ST131 are considered virulent extra-intestinal pathogens causing serious clinical complications such as urinary tract infection and bacteraemia. Our main objectives in this st...

Cefixime Methyl Ester
Cefixime
Cefixime EP Impurity A
CefixiMe Ethyl Ester Sodium Salt
Cefixime 1-Oxide
disodium,(6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(carboxylatomethoxyimino)acetyl]amino]-3-ethenyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
2-(2-{3-[({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)methyl]cyclopentyl}acetamido)pent-4-enoic acid
rac-5-{[(1R,2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclohexyl]formamido}-4-methylpentanoic acid
(2S,4S)-1-[(1RS,2SR)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclohexanecarbonyl]-4-hydroxypyrrolidine-2-carboxylic acid
(1RS&,2SR&)-2-[(1RS,2SR)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclopentaneamido]cyclohexane-1-carboxylic acid
rac-(1R,2S)-2-[1-(4-fluorophenyl)ethyl]cyclopropane-1-carboxylic acid
rac-(1R,3S)-3-({[1-benzyl-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)pyrrolidin-3-yl]formamido}methyl)-2,2-difluorocyclopropane-1-carboxylic acid
4-[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-5-methylhex-4-enamido]-3-methoxybutanoic acid
1-benzyl-3-{5-[({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)methyl]-1,3-oxazole-4-amido}pyrrolidine-3-carboxylic acid
3-{5-[({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)methyl]-1,3-oxazole-4-carbonyl}-1,3-thiazolidine-4-carboxylic acid
2-(1-{5-[({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)methyl]-1,3-oxazol-4-yl}-N-(2-methoxyethyl)formamido)acetic acid