CD437

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Names

[ CAS No. ]:
125316-60-1

[ Name ]:
CD437

[Synonym ]:
6-[3-(Adamantan-1-yl)-4-hydroxyphenyl]-2-naphthoic acid
O-Desmethyl Adapalene
2-Naphthalenecarboxylic acid, 6-(4-hydroxy-3-tricyclo[3.3.1.1]dec-1-ylphenyl)-
6-[3-(1-Adamantyl)-4-hydroxyphenyl]-2-naphthalene carboxylic acid AHPN
AHPN
6-[4-hydroxy-3-(tricyclo[3.3.1.1]dec-1-yl)phenyl]naphthalene-2-carboxylic acid
Cd 437
CD437

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
595.0±50.0 °C at 760 mmHg

[ Melting Point ]:
271.6-276ºC

[ Molecular Formula ]:
C27H26O3

[ Molecular Weight ]:
398.493

[ Flash Point ]:
327.7±26.6 °C

[ Exact Mass ]:
398.188202

[ PSA ]:
57.53000

[ LogP ]:
7.45

[ Vapour Pressure ]:
0.0±1.8 mmHg at 25°C

[ Index of Refraction ]:
1.689

[ Storage condition ]:
-20°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
QJ1975900
CHEMICAL NAME :
2-Naphthalenecarboxylic acid, 6-(4-hydroxy-3-tricyclo(3.3.1.1(3,7))dec-1-ylphenyl)-
CAS REGISTRY NUMBER :
125316-60-1
LAST UPDATED :
199806
DATA ITEMS CITED :
2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
15 mg/kg
SEX/DURATION :
female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 53,158,1996
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
15 mg/kg
SEX/DURATION :
female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 53,158,1996

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Safety Phrases ]:
S22

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
QJ1975900

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 6-(3-adamantan-1-yl-4-hydroxyphenyl)naphthalene-2-carboxylic acid methyl ester
  • 4-Bromophenol
  • Adamantan-1-ol
  • 2-(1-adamantyl)-4-bromophenol
  • 2-(1-adamantyl)-4-bromo-1-[(tert-butyldimethylsilyl)oxy]benzene
  • methyl 6-[3-(1-adamantyl)-4-[(tert-butyldimethylsilyl)oxy]phenyl]-2-naphthoate

DownStream

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