NPF-etoposide

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Names

[ CAS No. ]:
125830-36-6

[ Name ]:
NPF-etoposide

[Synonym ]:
4'-demethyl-4-p-fluoroaniline-4-desoxypodophyllotoxin
Npf-etoposide
(5AR,9S)-9-[(4-fluorophenyl)amino]-5-(4-hydroxy-3,5-dimethoxyphenyl)-5,8,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one
1,3-dioxol-6(5H)-one der.

Chemical & Physical Properties

[ Density]:
1.414g/cm3

[ Boiling Point ]:
689.7ºC at 760mmHg

[ Molecular Formula ]:
C27H24FNO7

[ Molecular Weight ]:
493.48000

[ Flash Point ]:
370.9ºC

[ Exact Mass ]:
493.15400

[ PSA ]:
95.48000

[ LogP ]:
4.43810

[ Vapour Pressure ]:
1.18E-19mmHg at 25°C

[ Index of Refraction ]:
1.648

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 4-Fluoroaniline
  • 4'-Demethylepipodophyllotoxin
  • (5R,5aR,8aR,9S)-5-(4-hydroxy-3,5-dimethoxyphenyl)-9-iodo-5,8,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one
  • Podophyllotoxin

DownStream

Related Compounds

  • α-Etoposide
  • picroetoposide
  • naphtho(2,3-b)furan-4,9-dione
  • 4'-Demethyl-1-O-[4,6-O-(aethyliden)-β-D-glucopyranosyl]-epipodophyllotoxin
  • 4'-Demethylepipodophyllotoxin
  • Komaline 3'-b-D-glucopyranoside