[(2S,5R)-5-(5-methyl-2,4-dioxopyrimidin-1-yl)-2,5-dihydrofuran-2-yl]methyl 2,2-dimethylpropanoate

Names

[ CAS No. ]:
126209-27-6

[ Name ]:
[(2S,5R)-5-(5-methyl-2,4-dioxopyrimidin-1-yl)-2,5-dihydrofuran-2-yl]methyl 2,2-dimethylpropanoate

[Synonym ]:
5'-pivaloyl-D4T
5'-Pivaloyl-2',3'-dideoxy-2',3'-didehydrothymidine

Chemical & Physical Properties

[ Density]:
1.225g/cm3

[ Molecular Formula ]:
C15H20N2O5

[ Molecular Weight ]:
308.33000

[ Exact Mass ]:
308.13700

[ PSA ]:
90.65000

[ LogP ]:
1.30020

[ Index of Refraction ]:
1.525

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • (5S)-5-(Hydroxymethyl)dihydro-2(3H)-furanone
  • Pivaloyl chloride
  • (S)-(5-oxotetrahydrofuran-2-yl)methyl pivalate
  • 1-(2',3'-dideoxy-2'-iodo-5'-O-(trimethylacetyl)-β-D-ribofuranosyl)thymine
  • TRIMETHYLACETIC ANHYDRIDE
  • Stavudine

DownStream

  • Stavudine