SR-12813

[ Density]:
1.117g/cm3

[ Boiling Point ]:
552.6ºC at 760mmHg

[ Molecular Formula ]:
C₂₄H₄₂O₇P₂

[ Molecular Weight ]:
504.53400

[ Flash Point ]:
288ºC

[ Exact Mass ]:
504.24100

[ PSA ]:
110.91000

[ LogP ]:
7.81780

[ Vapour Pressure ]:
8.02E-13mmHg at 25°C

[ Index of Refraction ]:
1.504

[ Storage condition ]:
-20℃

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

Dehydroepiandrosterone induces human CYP2B6 through the constitutive androstane receptor.

Drug Metab. Dispos. 35 , 1495-501, (2007)

Dehydroepiandrosterone (DHEA), the major precursor of androgens and estrogens, has several beneficial effects on the immune system, on memory function, and in modulating the effects of diabetes, obesi...

Cyclin-dependent kinase 2 negatively regulates human pregnane X receptor-mediated CYP3A4 gene expression in HepG2 liver carcinoma cells.

J. Biol. Chem. 283 , 30650-7, (2008)

The human pregnane X receptor (hPXR) regulates the expression of critical drug metabolism enzymes. One of such enzymes, cytochrome P450 3A4 (CYP3A4), plays critical roles in drug metabolism in hepatoc...

Isolation of mutant cells lacking Insig-1 through selection with SR-12813, an agent that stimulates degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase.

J. Biol. Chem. 279 , 43136-47, (2004)

Insig-1 and Insig-2 are membrane proteins of the endoplasmic reticulum that regulate lipid metabolism by the following two actions: 1) sterol-induced binding to 3-hydroxy-3-methylglutaryl-coenzyme A r...

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