Tyrphostin 51

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
788.2±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₃H₈N₄O₃

[ Molecular Weight ]:
268.228

[ Flash Point ]:
430.5±32.9 °C

[ Exact Mass ]:
268.059631

[ LogP ]:
0.04

[ Vapour Pressure ]:
0.0±2.8 mmHg at 25°C

[ Index of Refraction ]:
1.757

[ Storage condition ]:
2-8°C

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitors.

J. Med. Chem. 32 , 2344, (1989)

A novel class of low molecular weight protein tyrosine kinase inhibitors is described. These compounds constitute a systematic series of molecules with a progressive increase in affinity toward the su...

Blocking of EGF-dependent cell proliferation by EGF receptor kinase inhibitors.

Science 242(4880) , 933-5, (1988)

A systematic series of low molecular weight protein tyrosine kinase inhibitors were synthesized; they had progressively increasing affinity over a 2500-fold range toward the substrate site of epiderma...

Epidermal growth factor receptor inhibition by tyrphostin 51 induces apoptosis in luteinized granulosa cells.

J. Clin. Endocrinol. Metab. 90(1) , 469-73, (2005)

Growth factors may be involved in the control of ovarian cell fate and could contribute to regulation of ovarian cell apoptosis. Our objective is to test the hypothesis that, in human luteinized granu...

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