(+/-)-JQ1

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Names

[ CAS No. ]:
1268524-69-1

[ Name ]:
(+/-)-JQ1

[Synonym ]:
MFCD23726614

Chemical & Physical Properties

[ Density]:
1.33±0.1 g/cm3(Predicted)

[ Boiling Point ]:
610.4±65.0 °C(Predicted)

[ Molecular Formula ]:
C23H25ClN4O2S

[ Molecular Weight ]:
456.98800

[ Exact Mass ]:
456.13900

[ PSA ]:
97.61000

[ LogP ]:
4.96690

[ Appearance of Characters ]:
powder，white to beige

MSDS

Click to get detail MSDS

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 1H-Thieno[2,3-e]-1,4-diazepine-3-acetic acid, 5-(4-chlorophenyl)-2,3-dihydro-6,7-dimethyl-2-oxo-, 1,1-dimethylethyl ester, (3S)-

DownStream

Articles

Selective inhibition of BET bromodomains.

Nature 468(7327) , 1067-73, (2010)

Epigenetic proteins are intently pursued targets in ligand discovery. So far, successful efforts have been limited to chromatin modifying enzymes, or so-called epigenetic 'writers' and 'erasers'. Pote...

Therapeutic targeting of BET bromodomain proteins in castration-resistant prostate cancer.

Nature 510(7504) , 278-82, (2014)

Men who develop metastatic castration-resistant prostate cancer (CRPC) invariably succumb to the disease. Progression to CRPC after androgen ablation therapy is predominantly driven by deregulated and...


More Articles

Related Compounds

  • (+)-JQ1
  • (+)-JQ1 PA
  • JQ-1 carboxylic acid
  • (+/-)-4-(2-furyl)-butan-2-ol acetate
  • (+)-(3R,4S)-4-hydroxy-3-methylnonan-2-one
  • (+/-)-trans-3-Bromo-7-methoxy-2,2-dimethylchraman-4-ol
  • (2R,3R)-1-{[(9H-fluoren-9-yl)methoxy]carbonyl}-3-(trifluoromethyl)pyrrolidine-2-carboxylic acid
  • 7-[({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)methyl]-5H,6H,7H,8H-imidazo[1,2-a]pyridine-3-carboxylic acid
  • 4-hydrazinyl-6-methyl-1-propyl-1H-pyrazolo[3,4-d]pyrimidine
  • {5-[(2-Methylpiperazin-1-yl)methyl]piperidin-3-yl}methanamine
  • 2-(1-(4-Bromophenyl)vinyl)phenol
  • Ethyl 3-(3,3-difluorocyclobutyl)thiophene-2-carboxylate
  • 3-{[(Tert-butoxy)carbonyl]amino}-3-(2-fluorophenyl)butanoic acid
  • 4-Fluoro-2-methyl-1-(4-nitrophenyl)benzene
  • 2-[(3R)-3-hydroxybutyl]-4-nitrophenol
  • Tert-butyl 2,2-difluoro-2-(pyrrolidin-3-yl)acetate
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