(+)-JQ1

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Names

[ CAS No. ]:
1268524-70-4

[ Name ]:
(+)-JQ1

[Synonym ]:
(6s)-6-(2-Tert-butoxy-2-oxoethyl)-4-(4-chlorophenyl)-2,3,9-trimethyl-6,7-dihydrothieno[3,2-F][1,2,4]triazolo[4,3-A][1,4]diazepin-10-ium
(+)-JQ1
6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid, 4-(4-chlorophenyl)-2,3,9-trimethyl-, 1,1-dimethylethyl ester, (6S)-
JQ1
2-Methyl-2-propanyl [(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]acetate
UNII-1MRH0IMX0W
(+)-JQ-1

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
610.4±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C23H25ClN4O2S

[ Molecular Weight ]:
456.988

[ Flash Point ]:
322.9±34.3 °C

[ Exact Mass ]:
456.138672

[ PSA ]:
97.61000

[ LogP ]:
4.49

[ Appearance of Characters ]:
white to beige

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.657

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
DMSO: soluble20mg/mL, clear

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 1H-Thieno[2,3-e]-1,4-diazepine-3-acetic acid, 5-(4-chlorophenyl)-2,3-dihydro-6,7-dimethyl-2-oxo-, 1,1-dimethylethyl ester, (3S)-
  • Acethydrazide
  • (2-amino-4,5-dimethylthiophen-3-yl)(4-chlorophenyl)methanone
  • 4-Chlorobenzoylacetonitrile

DownStream

Articles

Epigenetic chemical probes. Müller S and Brown PJ

Clin. Pharmacol. Ther. 92(6) , 689-93, (2012)


More Articles

Related Compounds

  • (+)-JQ1 PA
  • (+)-JQ1 carboxylic acid
  • (+/-)-JQ1
  • (+/-)-4-(2-furyl)-butan-2-ol acetate
  • (+)-(3R,4S)-4-hydroxy-3-methylnonan-2-one
  • (+/-)-trans-3-Bromo-7-methoxy-2,2-dimethylchraman-4-ol
  • 3-[3-(Trifluoromethyl)pyridin-2-yl]but-3-en-1-amine
  • 3-(2-Chloro-3,4-dimethoxyphenyl)but-3-en-1-amine
  • Methyl 4-amino-4-(2,6-difluoro-3-methylphenyl)butanoate
  • 2,5-dimethyl-1-(2-methylpropyl)-3-(2-nitroethenyl)-1H-pyrrole
  • 3,3-Difluoro-1-(pent-1-en-1-yl)cyclobutan-1-amine
  • 1-{1-Methyl-1,4-diazaspiro[5.5]undecan-4-yl}prop-2-en-1-one
  • 1-{4-[4-(3-Methylpyrazin-2-yl)piperazine-1-carbonyl]-4-phenylpiperidin-1-yl}prop-2-en-1-one
  • Propan-2-yl 3-(6-bromo-4-chloropyridin-3-yl)-2-cyanoprop-2-enoate
  • 4-methyl-3-(4-methyl-1H-imidazol-1-yl)benzaldehyde
  • 5-(1,4-dimethyl-1H-pyrazol-5-yl)-1,2-oxazole-4-carboxylic acid
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