(+)-JQ1

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Names

[ Name ]:
(+)-JQ1

[Synonym ]:
(6s)-6-(2-Tert-butoxy-2-oxoethyl)-4-(4-chlorophenyl)-2,3,9-trimethyl-6,7-dihydrothieno[3,2-F][1,2,4]triazolo[4,3-A][1,4]diazepin-10-ium
(+)-JQ1
6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid, 4-(4-chlorophenyl)-2,3,9-trimethyl-, 1,1-dimethylethyl ester, (6S)-
JQ1
2-Methyl-2-propanyl [(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]acetate
UNII-1MRH0IMX0W
(+)-JQ-1

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
610.4±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₃H₂₅ClN₄O₂S

[ Molecular Weight ]:
456.988

[ Flash Point ]:
322.9±34.3 °C

[ Exact Mass ]:
456.138672

[ PSA ]:
97.61000

[ LogP ]:
4.49

[ Appearance of Characters ]:
white to beige

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.657

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
DMSO: soluble20mg/mL, clear

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

1H-Thieno[2,3-e]-1,4-diazepine-3-acetic acid, 5-(4-chlorophenyl)-2,3-dihydro-6,7-dimethyl-2-oxo-, 1,1-dimethylethyl ester, (3S)-
Acethydrazide
(2-amino-4,5-dimethylthiophen-3-yl)(4-chlorophenyl)methanone
4-Chlorobenzoylacetonitrile

DownStream

Articles

Epigenetic chemical probes. Müller S and Brown PJ

Clin. Pharmacol. Ther. 92(6) , 689-93, (2012)

(+)-JQ1 PA
(+)-JQ1 carboxylic acid
(+/-)-JQ1
(+/-)-4-(2-furyl)-butan-2-ol acetate
(+)-(3R,4S)-4-hydroxy-3-methylnonan-2-one
(+/-)-trans-3-Bromo-7-methoxy-2,2-dimethylchraman-4-ol
4-((1,1-dioxido-3-oxo-2-(m-tolyl)-2H-benzo[e][1,2,4]thiadiazin-4(3H)-yl)methyl)benzonitrile
4-[2-(4-fluorophenyl)-2-oxoethyl]-2-(3-methylphenyl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide
1-(4-bromophenyl)-4-((4-ethylphenyl)sulfonyl)-1H-1,2,3-triazol-5-amine
(2Z)-6-fluoro-2-[(3-fluorophenyl)imino]-2H-chromene-3-carbothioamide
methyl 3-((5-(3,4-dimethylphenyl)-4,6-dioxo-4,5,6,6a-tetrahydropyrrolo[3,4-d][1,2,3]triazol-1(3aH)-yl)methyl)-4-methoxybenzoate
2-((4-(4-fluorophenyl)-3-oxo-3,4-dihydropyrazin-2-yl)thio)-N-(2-methoxyphenyl)acetamide
Methyl 3-[{2-[(2-methylphenyl)amino]-2-oxoethyl}(phenyl)sulfamoyl]thiophene-2-carboxylate
Methyl 3-[{2-[(2,3-dimethylphenyl)amino]-2-oxoethyl}(phenyl)sulfamoyl]thiophene-2-carboxylate
Methyl 3-[{2-[(2,5-dimethylphenyl)amino]-2-oxoethyl}(phenyl)sulfamoyl]thiophene-2-carboxylate
Methyl 3-[{2-[(3,5-dimethylphenyl)amino]-2-oxoethyl}(phenyl)sulfamoyl]thiophene-2-carboxylate

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