(-)-JQ-1

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Names

[ Name ]:
(-)-JQ-1

[Synonym ]:
6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid, 4-(4-chlorophenyl)-2,3,9-trimethyl-, 1,1-dimethylethyl ester, (6R)-
2-Methyl-2-propanyl [(6R)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]acetate
(R)-(-)-JQ1 Enantiomer

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
610.4±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₃H₂₅ClN₄O₂S

[ Molecular Weight ]:
456.988

[ Flash Point ]:
322.9±34.3 °C

[ Exact Mass ]:
456.138672

[ PSA ]:
97.61000

[ LogP ]:
4.49

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.657

[ Storage condition ]:
-20°C

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Articles

Targeting bromodomains: epigenetic readers of lysine acetylation.

Nat. Rev. Drug Discov. 13(5) , 337-56, (2014)

Lysine acetylation is a key mechanism that regulates chromatin structure; aberrant acetylation levels have been linked to the development of several diseases. Acetyl-lysine modifications create dockin...

Epigenetic chemical probes. Müller S and Brown PJ

Clin. Pharmacol. Ther. 92(6) , 689-93, (2012)

Targeting chromatin readers. James LI and Frye SV

Clin. Pharmacol. Ther. 93(4) , 312-4, (2013)

JQ-1 carboxylic acid
(+)-JQ1
8-Hydroxyquinoline
Daphnetin 7-methyl ether
2-[1-(2-hydroxy-3,5-dimethylphenyl)cyclohexyl]-4,6-dimethylphenol
3-[1-(2,5-dimethylthiophen-3-yl)octadecyl]-4-propan-2-ylideneoxolane-2,5-dione
2-((5-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethyl)-1,3,4-oxadiazol-2-yl)thio)-N-(2-ethylphenyl)acetamide
2-((5-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethyl)-1,3,4-oxadiazol-2-yl)thio)-N-(3-fluoro-4-methylphenyl)acetamide
2-((5-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethyl)-1,3,4-oxadiazol-2-yl)thio)-N-(4-fluorobenzyl)acetamide
N-(3-(2-((5-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethyl)-1,3,4-oxadiazol-2-yl)thio)acetyl)phenyl)acetamide
N-(5-(thiophen-2-ylmethyl)-1,3,4-oxadiazol-2-yl)benzamide
3-methyl-N-(5-(thiophen-2-ylmethyl)-1,3,4-oxadiazol-2-yl)benzamide
4-chloro-N-(5-(thiophen-2-ylmethyl)-1,3,4-oxadiazol-2-yl)benzamide
2-chloro-N-(5-(thiophen-2-ylmethyl)-1,3,4-oxadiazol-2-yl)benzamide
4-(N,N-diethylsulfamoyl)-N-(5-(thiophen-2-ylmethyl)-1,3,4-oxadiazol-2-yl)benzamide
4-fluoro-N-(5-(thiophen-2-ylmethyl)-1,3,4-oxadiazol-2-yl)benzamide

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