LGX 818

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Names

[ CAS No. ]:
1269440-17-6

[ Name ]:
LGX 818

[Synonym ]:
LGX-818
Encorafenib
NVP-LGX818-NXA
LGX818
Encorafenib (LGX818)
methyl N-[(2S)-1-({4-[3-(5-chloro-2-fluoro-3-methanesulfonamidophenyl)-1-(propan-2-yl)-1H-pyrazol-4-yl]pyrimidin-2-yl}amino)propan-2-yl]carbamate
T6N CNJ BM1Y1&MVO1& D- DT5NNJ AY1&1 CR CG FF EMSW1 &&S Form
UNII-8L7891MRB6
Carbamic acid, N-[(1S)-2-[[4-[3-[5-chloro-2-fluoro-3-[(methylsulfonyl)amino]phenyl]-1-(1-methylethyl)-1H-pyrazol-4-yl]-2-pyrimidinyl]amino]-1-methylethyl]-, methyl ester
(S)-methyl (1-((4-(3-(5-chloro-2-fluoro-3-(methylsulfonamido)phenyl)-1-isopropyl-1H-pyrazol-4-yl)pyrimidin-2-yl)amino)propan-2-yl)carbamate
Methyl [(2S)-1-{[4-(3-{5-chloro-2-fluoro-3-[(methylsulfonyl)amino]phenyl}-1-isopropyl-1H-pyrazol-4-yl)-2-pyrimidinyl]amino}-2-propanyl]carbamate

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Molecular Formula ]:
C22H27ClFN7O4S

[ Molecular Weight ]:
540.011

[ Exact Mass ]:
539.151794

[ PSA ]:
152.00000

[ LogP ]:
2.56

[ Index of Refraction ]:
1.641

[ Storage condition ]:
-20℃

[ Water Solubility ]:
Insuluble (7.0E-4 g/L) (25 ºC)

Related Compounds

  • TRX-818 sodium
  • methyl(4,6-diamino-2-[5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl)carbamate di-dimethyl sulphoxide solvate
  • (2Z)-5-chloro-2-[(2E)-2-[(5-chloro-1,3-benzothiazol-2-yl)methylidene]butylidene]-3-ethyl-1,3-benzothiazole
  • Lemildipine
  • disodium [4-[[4,5-dihydro-3-methyl-5-oxo-1-(3-sulphophenyl)-1H-pyrazol-4-yl]azo]-3-hydroxynaphthalene-1-sulphonato(4-)]chromate(2-)
  • L-817,818
  • 4-{[1-(3-Fluoropyridin-2-yl)piperidin-4-yl]methoxy}pyridine-2-carboxamide
  • 3-(Pyrrolidine-1-carbonyl)-1-{thieno[2,3-d]pyrimidin-4-yl}pyrrolidine
  • 4-{[1-(5-Fluoropyridin-2-yl)piperidin-4-yl]methoxy}pyridine-2-carboxamide
  • 1-[(4-Fluorophenyl)methyl]-4-[3-(2-methoxyethyl)-1,2,4-thiadiazol-5-yl]piperazin-2-one
  • 2-Chloro-3-fluoro-5-iodo-6-methoxypyridin-4-amine
  • N-cyclopropyl-1-(4-methoxy-1,3-benzothiazol-2-yl)pyrrolidine-3-carboxamide
  • N-cyclopropyl-1-(5-methoxy-1,3-benzothiazol-2-yl)pyrrolidine-3-carboxamide
  • 4-({1-[2-Methyl-6-(trifluoromethyl)pyrimidin-4-yl]piperidin-4-yl}methoxy)pyridine-2-carboxamide
  • 1-{8-cyclopentyl-5-methyl-7-oxo-7H,8H-pyrido[2,3-d]pyrimidin-2-yl}-N-cyclopropylpyrrolidine-3-carboxamide
  • N-cyclopropyl-1-(6-methoxyquinolin-2-yl)pyrrolidine-3-carboxamide
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