Titanocene dichloride

Suppliers

Names

[ Name ]:
Titanocene dichloride

[Synonym ]:
Titanocene dichloride
EINECS 215-035-9
Bis(cyclopentadienyl)titanium(IV) dichloride
Di(cyclopentadienyl)titanium(IV) dichloride
MFCD00003723
Bis(Cyclopentadienyl)Titanium Dichloride
Dichlorobis(1,3-cyclopentadiene)titaniumDichlorodicyclopentadienyltitanium
Dichlorotitanium(2+) di(2,4-cyclopentadienide)
Dichlorotitanocene

Chemical & Physical Properties

[ Density]:
1.6

[ Boiling Point ]:
41.5ºC at 760 mmHg

[ Melting Point ]:
287-289ºC

[ Molecular Formula ]:
C₁₀H₁₀Cl₂Ti

[ Molecular Weight ]:
248.96

[ Exact Mass ]:
247.963898

[ LogP ]:
3.29540

[ Stability ]:
Stable. Incompatible with strong oxidizing agents. Decomposes in water. Moisture sensitive.

[ Water Solubility ]:
slow decomposition

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XR2050000

CHEMICAL NAME :: Titanium, dichloro-di-pi-cyclopentadienyl-

CAS REGISTRY NUMBER :: 1271-19-8

LAST UPDATED :: 199710

DATA ITEMS CITED :: 24

MOLECULAR FORMULA :: C10-H10-Cl2-Ti

MOLECULAR WEIGHT :: 249.00

WISWESSER LINE NOTATION :: L50J 0-TI-GG- 0L50J

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 25 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 60 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - changes in motor activity (specific assay)

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 180 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 6 gm/kg/14D-I

TOXIC EFFECTS :: Kidney, Ureter, Bladder - other changes in urine composition Blood - pigmented or nucleated red blood cells Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4030 mg/kg/13W-I

TOXIC EFFECTS :: Cardiac - changes in heart weight Endocrine - changes in thymus weight Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 26 gm/kg/2Y-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 720 mg/kg/2Y-I

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Blood - lymphoma, including Hodgkin's disease Tumorigenic - tumors at site of application

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 75 mg/kg

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Blood - lymphoma, including Hodgkin's disease Tumorigenic - tumors at site of application

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 900 mg/kg/2Y-I

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Musculoskeletal - tumors Tumorigenic - tumors at site of application

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 430 mg/kg/81W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Blood - lymphoma, including Hodgkin's disease Tumorigenic - tumors at site of application

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 30 mg/kg

SEX/DURATION :: female 10 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 60 mg/kg

SEX/DURATION :: female 10 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)

MUTATION DATA

TYPE OF TEST :: Morphological transformation

TEST SYSTEM :: Rodent - hamster Embryo

DOSE/DURATION :: 100 ug/L

REFERENCE :: JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC) V.61-79, 1978-87. For publisher information, see JNCIEQ. Volume(issue)/page/year: 67,1303,1981

Safety Information

[ Hazard Codes ]:
T:Toxic;Xi:Irritant;

[ Risk Phrases ]:
R33;R34;R37/38;R40;R61

[ Safety Phrases ]:
S26-S36/37/39-S45-S6-S7/8

[ RIDADR ]:
UN3261

[ WGK Germany ]:
3

[ RTECS ]:
XR2050000

[ Packaging Group ]:
II

[ Hazard Class ]:
8

[ HS Code ]:
29310095

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

Chlorotrimethylsilane
Petasis reagent
bis(cyclopentadienyl)difluorotitanium(iv)
1,4-{(Cp)2Ti}2Se4
superheavy water
1,3-Cyclopentadien-1-yltitanium(3+) trichloride
Cyclopentadiene
(η3-crotyl)bis(cyclopentadienyl)titanium

DownStream

dicarbonylcyclopentadienylcobalt
5,5'-bis(1,3-cyclopentadiene)
Cyclopentadiene
2-Methyl-3-butenoic acid
titanocene
titanium monoxide
bis(cyclopentadienyl)difluorotitanium(iv)
[2-(N,N-dimethylaminomethyl)phenyl]di-n-butyltin(IV) chloride
[2-(N,N-dimethylaminomethyl)phenyl]diphenyltin(IV) chloride

Customs

[ HS Code ]: 2903890090

[ Summary ]:
2903890090. halogenated derivatives of cyclanic, cyclenic or cyclotherpenic hydrocarbons. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%

Related Compounds

titanocene bis(hydrogenmaleinate)
titanocene dibromide
titanocene bis(4-aminothiophenolate)
titanocene bis(trichloroacetate)
titanocene pentaselenide
Titanocene Bis(trifluoromethanesulfonate)
2-(2-Bromoethyl)-1-chloro-3-methylbenzene
2-(1-bromopropan-2-yl)-5-chloro-1H-indole
2-(1-bromopropan-2-yl)-4H,5H,6H-cyclopenta[b]thiophene
2-(2-Bromopropyl)-1,3-difluoro-4-methylbenzene
N-ethyl-3-(2-oxo-1,3-oxazolidin-5-yl)benzamide
2-Cyclopentyl-3-[(propan-2-yl)carbamoyl]propanoic acid
4-(3-Chloro-2-methoxyphenyl)pyrrolidin-2-one
4-(3-bromo-1-methyl-1H-pyrazol-5-yl)pyrrolidin-2-one
2-Amino-3-[3-(ethylcarbamoyl)phenyl]propanoic acid
3-Amino-1-(2-chloro-5-fluorophenyl)cyclobutane-1-carboxylic acid

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.