Y-27152

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Names

[ CAS No. ]:
127408-30-4

[ Name ]:
Y-27152

[Synonym ]:
Conantokin-R
Y-27152

Chemical & Physical Properties

[ Density]:
1.28g/cm3

[ Boiling Point ]:
513.4ºC at 760mmHg

[ Molecular Formula ]:
C21H22N2O4

[ Molecular Weight ]:
366.41

[ Flash Point ]:
264.3ºC

[ Exact Mass ]:
366.15800

[ PSA ]:
82.79000

[ LogP ]:
3.11158

[ Vapour Pressure ]:
2.29E-11mmHg at 25°C

[ Index of Refraction ]:
1.617

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AB5956333
CHEMICAL NAME :
Acetamide, N-(6-cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-be nzopyran-4-yl)- N-(phenylmethoxy)-, (3S-trans)-
CAS REGISTRY NUMBER :
127408-30-4
LAST UPDATED :
199603
DATA ITEMS CITED :
5
MOLECULAR FORMULA :
C21-H22-N2-O4
MOLECULAR WEIGHT :
366.45

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>2 gm/kg
TOXIC EFFECTS :
Cardiac - other changes Vascular - BP lowering not characterized in autonomic section Lungs, Thorax, or Respiration - other changes
REFERENCE :
CDREEA Cardiovascular Drug Reviews. (Raven Press, 1185 Avenue of the Americas, New York, NY 10036) V.6- 1988- Volume(issue)/page/year: 9,372,1991
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>2 gm/kg
TOXIC EFFECTS :
Cardiac - other changes Vascular - BP lowering not characterized in autonomic section Lungs, Thorax, or Respiration - other changes
REFERENCE :
CDREEA Cardiovascular Drug Reviews. (Raven Press, 1185 Avenue of the Americas, New York, NY 10036) V.6- 1988- Volume(issue)/page/year: 9,372,1991
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
10 mg/kg
TOXIC EFFECTS :
Cardiac - other changes Vascular - BP lowering not characterized in autonomic section Lungs, Thorax, or Respiration - other changes
REFERENCE :
CDREEA Cardiovascular Drug Reviews. (Raven Press, 1185 Avenue of the Americas, New York, NY 10036) V.6- 1988- Volume(issue)/page/year: 9,372,1991 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
910 mg/kg/13W-I
TOXIC EFFECTS :
Cardiac - changes in heart weight Vascular - BP lowering not characterized in autonomic section Endocrine - changes in thymus weight
REFERENCE :
CDREEA Cardiovascular Drug Reviews. (Raven Press, 1185 Avenue of the Americas, New York, NY 10036) V.6- 1988- Volume(issue)/page/year: 9,372,1991
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
27300 ug/kg/13W-I
TOXIC EFFECTS :
Cardiac - changes in heart weight Vascular - BP lowering not characterized in autonomic section
REFERENCE :
CDREEA Cardiovascular Drug Reviews. (Raven Press, 1185 Avenue of the Americas, New York, NY 10036) V.6- 1988- Volume(issue)/page/year: 9,372,1991

Related Compounds

  • Y-320
  • Y-26763
  • Y(N,N'-diisopropyl-N'-bis(trimethylsilyl)guanidinate)(CH2SiMe3)2(THF)2
  • Y(N,N'-diisopropyl-N'-bis(trimethylsilyl)guanidinate)(t-Bu)2(THF)
  • Y(hfac)3(H2O)2
  • N-((5-(furan-2-yl)isoxazol-3-yl)methyl)-3-(trifluoromethyl)benzamide
  • N-((5-(furan-2-yl)isoxazol-3-yl)methyl)-4-(trifluoromethyl)benzamide
  • N-((5-(furan-2-yl)isoxazol-3-yl)methyl)-1-naphthamide
  • (Z)-N-((5-(furan-2-yl)isoxazol-3-yl)methyl)-3-phenylacrylamide
  • (Z)-3-(benzo[d][1,3]dioxol-5-yl)-N-((5-(furan-2-yl)isoxazol-3-yl)methyl)acrylamide
  • (Z)-N-((5-(furan-2-yl)isoxazol-3-yl)methyl)-3-(3,4,5-trimethoxyphenyl)acrylamide
  • N-((5-(furan-2-yl)isoxazol-3-yl)methyl)-2-phenoxyacetamide
  • 2-(4-chlorophenoxy)-N-((5-(furan-2-yl)isoxazol-3-yl)methyl)acetamide
  • 2-(2,4-dichlorophenoxy)-N-((5-(furan-2-yl)isoxazol-3-yl)methyl)acetamide
  • N-((5-(furan-2-yl)isoxazol-3-yl)methyl)-2-(naphthalen-2-yloxy)acetamide
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