cyclopenta-1,3-diene,cyclopentane,dichloroniobium

Names

[ CAS No. ]:
12793-14-5

[ Name ]:
cyclopenta-1,3-diene,cyclopentane,dichloroniobium

[Synonym ]:
MFCD00009949

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₀H₁₀Cl₂Nb

[ Molecular Weight ]:
293.99900

[ Exact Mass ]:
292.92200

[ LogP ]:
3.42200

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QU0400000

CHEMICAL NAME :: Niobium, dichlorobis(eta(sup 5)-2,4-cyclopentadien-1-yl)-

CAS REGISTRY NUMBER :: 12793-14-5

LAST UPDATED :: 198209

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C10-H10-Cl2-Nb

MOLECULAR WEIGHT :: 294.01

WISWESSER LINE NOTATION :: G-NB-GR&R

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 35 mg/kg

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay) Skin and Appendages - hair Tumorigenic - active as anti-cancer agent

REFERENCE :: JINCAO Journal of Inorganic and Nuclear Chemistry. (Oxford, UK) V.1-43, 1955-81. Volume(issue)/page/year: 42,1789,1980

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
26-36

[ RIDADR ]:
NONH for all modes of transport

[ RTECS ]:
QU0400000

[ HS Code ]:
2903890090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

1,2-PHENYLENE PHOSPHOROCHLORIDITE
bis(cyclopentadienyl)niobium trihydride
DIETHYL CHLOROPHOSPHITE
(Cp)2Nb(η-1-(CH3)3CC5H4)Cl
(η2-disulfido)methyl-bis(η5-cyclopentadienyl)niobium

DownStream

Customs

[ HS Code ]: 2903890090

[ Summary ]:
2903890090. halogenated derivatives of cyclanic, cyclenic or cyclotherpenic hydrocarbons. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%

Articles

A (1)H NMR study of the interaction of antitumor metallocenes with glutathione.

J. Inorg. Biochem. 86(2-3) , 611-6, (2001)

The interaction of the antitumor active metallocene dihalides Cp(2)MCl(2) (M=Ti, Nb, Mo) and 1 equiv. of glutathione was studied by (1)H NMR spectroscopy at pD 2-7 in 4 mM NaCl solutions. No interacti...

Organometallic anticancer agents. 2. Aqueous chemistry and interaction of niobocene dichloride with nucleic acid constituents and amino acids.

J. Med. Chem. 39(25) , 5012-6, (1996)

The solution chemistry and interactions of niobocene dichloride, Cp2NbCl2, with nucleosides, nucleotides, and amino acids has been studied by 1H and 31P NMR spectroscopy. The 1H NMR spectrum of Cp2NbC...

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