N-chlorosuccinimide

Suppliers

Names

[ CAS No. ]:
128-09-6

[ Name ]:
N-chlorosuccinimide

[Synonym ]:
succinimide, N-chloro-
Chlorosuccinimide
EINECS 204-878-8
N-chlorobutanimide
1-Chloro-2,5-pyrrolidinedione
2,5-Pyrrolidinedione, 1-chloro-
Succinimide, N-chloro- (8CI)
1-chloropyrrolidine-2,5-dione
N-Chlorosuccinimide
MFCD00005511

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
200.5±23.0 °C at 760 mmHg

[ Melting Point ]:
148-150 °C(lit.)

[ Molecular Formula ]:
C₄H₄ClNO₂

[ Molecular Weight ]:
133.533

[ Flash Point ]:
75.1±22.6 °C

[ Exact Mass ]:
132.993057

[ PSA ]:
37.38000

[ LogP ]:
-0.87

[ Vapour Pressure ]:
0.3±0.4 mmHg at 25°C

[ Index of Refraction ]:
1.532

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UY1013500

CHEMICAL NAME :: 2,5-Pyrrolidinedione, 1-chloro-

CAS REGISTRY NUMBER :: 128-09-6

BEILSTEIN REFERENCE NO. :: 0113915

LAST UPDATED :: 199701

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C4-H4-Cl-N-O2

MOLECULAR WEIGHT :: 133.54

WISWESSER LINE NOTATION :: T5VNVTJ BG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PHRPA6 Public Health Reports. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1878- Volume(issue)/page/year: 59,541,1944

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - chronic pulmonary edema Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: PHRPA6 Public Health Reports. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1878- Volume(issue)/page/year: 59,541,1944 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 15 gm/kg/40D-C

TOXIC EFFECTS :: Behavioral - food intake (animal) Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

REFERENCE :: PHRPA6 Public Health Reports. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1878- Volume(issue)/page/year: 59,541,1944

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 5800 mg/kg/5W-I

TOXIC EFFECTS :: Blood - pigmented or nucleated red blood cells

REFERENCE :: PHRPA6 Public Health Reports. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1878- Volume(issue)/page/year: 59,541,1944 ** TUMORIGENIC DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 840 mg/kg/70W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - tumors at site of application

REFERENCE :: JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8. Volume(issue)/page/year: 53,695,1974

Safety Information

[ Symbol ]:

GHS05, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H302-H314

[ Precautionary Statements ]:
P280-P305 + P351 + P338-P310

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ Hazard Codes ]:
C:Corrosive

[ Risk Phrases ]:
R22;R34

[ Safety Phrases ]:
S26-S36/37/39-S45-S37/39

[ RIDADR ]:
UN 3261 8/PG 2

[ WGK Germany ]:
3

[ RTECS ]:
UY1013500

[ Packaging Group ]:
III

[ Hazard Class ]:
8

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

6-Chlorooxazolo[4,5-b]pyridin-2(3H)-one
5-Bromo-3-chloro-2-pyridinamine
DBPCl
Cyclohexanone
1-(PHENYLTHIO)PYRROLIDINE-2,5-DIONE
Succinimide
2,5-Pyrrolidinedione,1-(2-chloroethyl)-
2-(Chloromethyl)pyrazine
3-Chloro-5-nitro-1H-indazole
N-iodosuccinimide

Customs

[ HS Code ]: 2925190090

[ Summary ]:
2925190090 other imides and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

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