N-ethylmaleimide

Suppliers

Names

[ CAS No. ]:
128-53-0

[ Name ]:
N-ethylmaleimide

[Synonym ]:
N-ethylmaleimide
EINECS 204-892-4
1H-Pyrrole-2,5-dione, 1-ethyl-
n-ethyl-maleimid
MFCD00005509
1-ethylmaleimide
N-ethyl-maleimide
N-ethylmaleic imide
ethvlmaleimide
n-ethvlmaleimide
1-Ethyl-1H-pyrrole-2,5-dione
N-Ethylmaleinimid
Ethylmaleimide

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
210.0±9.0 °C at 760 mmHg

[ Melting Point ]:
43-46 °C(lit.)

[ Molecular Formula ]:
C6H7NO2

[ Molecular Weight ]:
125.13

[ Flash Point ]:
73.3±0.0 °C

[ Exact Mass ]:
125.047676

[ PSA ]:
37.38000

[ LogP ]:
0.68

[ Vapour Pressure ]:
0.2±0.4 mmHg at 25°C

[ Index of Refraction ]:
1.514

[ Storage condition ]:
2-8°C

[ Stability ]:
Stable. Combustible. Incompatible with strong oxidizing agents. Refrigerate.

[ Water Solubility ]:
1 g/L (20 ºC)

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UX9625000
CHEMICAL NAME :
1H-Pyrrole-2,5-dione, 1-ethyl-
CAS REGISTRY NUMBER :
128-53-0
BEILSTEIN REFERENCE NO. :
0112448
LAST UPDATED :
199710
DATA ITEMS CITED :
15
MOLECULAR FORMULA :
C6-H7-N-O2
MOLECULAR WEIGHT :
125.14
WISWESSER LINE NOTATION :
T5VNVJ B2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
17 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intracerebral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1669 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
25 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :
DNA inhibition
TEST SYSTEM :
Rodent - hamster Lung
DOSE/DURATION :
750 nmol/L
REFERENCE :
32YWA5 "Radiation Research, Biomedical, Chemical, and Physical Perspectives, Proceedings of the International Congress of Radiation Research, 5th, Seattle, 1974," Nygaard, O.F., et al., eds., New York, Academic Press, Inc., 1975 Volume(issue)/page/year: -,742,1975 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4314 No. of Facilities: 132 (estimated) No. of Industries: 2 No. of Occupations: 5 No. of Employees: 2547 (estimated) No. of Female Employees: 1922 (estimated)

Safety Information

[ Symbol ]:

GHS05, GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H300-H311-H314-H317

[ Precautionary Statements ]:
P264-P280-P301 + P310-P305 + P351 + P338-P310

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ Hazard Codes ]:
T+:Verytoxic;

[ Risk Phrases ]:
R20/21;R28;R34;R43

[ Safety Phrases ]:
S26-S28-S36/37/39-S45-S28A

[ RIDADR ]:
UN 2928 6.1/PG 2

[ WGK Germany ]:
3

[ RTECS ]:
UX9625000

[ Packaging Group ]:
II

[ Hazard Class ]:
6.1

[ HS Code ]:
2925190090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Maleic anhydride
  • Ethylamine hydrochloride
  • n-ethylmaleamic acid
  • (2E)-4-(Ethylamino)-4-oxo-2-butenoic acid

DownStream

  • n-ethylmaleamic acid
  • Succinimide, N-ethyl-
  • 3-(1-Ethyl-3-pyrrolidinyl)-1H-indole
  • 1-ethyl-3-phenylselanyl-pyrrolidine-2,5-dione
  • Ethyl 2,8-diethyl-1,3,7,9-tetraoxooctahydro-1H-pyrrolo(3,4-d)pyrrolo(3,4:4,5)isoxazolo(2,3-b)isoxazole-9b(6aH)-carboxylate
  • 7-amino-2-ethyl-6-methylpyrrolo[3,4-c]pyridine-1,3-dione
  • 4,5,6,7-tetrachloro-2-ethylisoindole-1,3-dione

Customs

[ HS Code ]: 2925190090

[ Summary ]:
2925190090 other imides and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

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  • d5-N-ethylmaleimide
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