Romidepsin (FK228, Depsipeptide)
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Names
[ CAS No. ]:
128517-07-7
[ Name ]:
Romidepsin (FK228, Depsipeptide)
[Synonym ]:
(1S,4S,7Z,10S,21R)-7-ethylidene-4,21-di(propan-2-yl)-2-oxa-12,13-dithia-5,8,20,23-tetraazabicyclo[8.7.6]tricos-16-ene-3,6,9,19,22-pentone
2-Oxa-12,13-dithia-5,8,20,23-tetraazabicyclo[8.7.6]tricos-16-ene-3,6,9,19,22-pentone, 7-ethylidene-4,21-bis(1-methylethyl)-, (1S,4S,7Z,10S,21R)-
2-Oxa-12,13-dithia-5,8,20,23-tetraazabicyclo[8.7.6]tricos-16-ene-3,6,9,19,22-pentone, 7-ethylidene-4,21-bis(1-methylethyl)-, (1S,4S,7Z,10S,16Z,21R)-
Chromadax
Depsipeptide
(1S,4S,7Z,10S,16E,21R)-7-ethylidene-4,21-di(propan-2-yl)-2-oxa-12,13-dithia-5,8,20,23-tetrazabicyclo[8.7.6]tricos-16-ene-3,6,9,19,22-pentone
Romidepsin (FK228,depsipeptide)
FK-228
(1S,4S,7Z,10S,16Z,21R)-7-Ethylidene-4,21-diisopropyl-2-oxa-12,13-dithia-5,8,20,23-tetraazabicyclo[8.7.6]tricos-16-ene-3,6,9,19,22-pentone
Romidepsin
(1S,4S,7Z,10S,21R)-7-Ethylidene-4,21-diisopropyl-2-oxa-12,13-dithia-5,8,20,23-tetraazabicyclo[8.7.6]tricos-16-ene-3,6,9,19,22-pentone
Istodax
Chemical & Physical Properties
[ Density]:
1.2±0.1 g/cm3
[ Boiling Point ]:
942.8±65.0 °C at 760 mmHg
[ Melting Point ]:
219-224°C
[ Molecular Formula ]:
C24H36N4O6S2
[ Molecular Weight ]:
540.696
[ Flash Point ]:
524.0±34.3 °C
[ Exact Mass ]:
540.207642
[ PSA ]:
193.30000
[ LogP ]:
0.95
[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C
[ Index of Refraction ]:
1.529
[ Storage condition ]:
Amber Vial, -20°C Freezer, Under Inert Atmosphere
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- YV9399000
- CHEMICAL NAME :
- L-Valine, N-(3-hydroxy-7-mercapto-1-oxo-4-heptenyl)-D-valyl-D-c ysteinyl-(Z)-2,3-dide hydro-2- aminobutanoyl-, ti-lactone, cyclic (1-2)-disulfide, (S-(E))-
- CAS REGISTRY NUMBER :
- 128517-07-7
- LAST UPDATED :
- 199610
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C24-H36-N4-O6-S2
- MOLECULAR WEIGHT :
- 540.76
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 6400 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 47,301,1994
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 10 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 47,301,1994
Safety Information
[ RIDADR ]:
NONH for all modes of transport
[ RTECS ]:
YV9399000
[ HS Code ]:
29349990
Synthetic Route
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