Buclizine dihydrochloride

Suppliers

Names

[ CAS No. ]:
129-74-8

[ Name ]:
Buclizine dihydrochloride

[Synonym ]:
1-(p-Chlorobenzhydryl)-4-(p-tert-butylbenzyl)piperazine dihydrochloride
Posdel
1-(p-Chlorobenzhydryl)-4-(p-tert-butylbenzyl)diethylenediamine dihydrochloride
1-(4-tert-Butylbenzyl)-4-[(4-chlorophenyl)(phenyl)methyl]piperazine dihydrochloride
MFCD00242700
Buclina
1-(4-(tert-Butyl)benzyl)-4-((4-chlorophenyl)(phenyl)methyl)piperazine dihydrochloride
1-(p-tert-Butylbenzyl)-4-(p-chloro-a-phenylbenzyl)piperazine Dihydrochloride
1-[(4-Chlorophenyl)(phenyl)methyl]-4-[4-(2-methyl-2-propanyl)benzyl]piperazine dihydrochloride
Postafen
BUCLIZINE, DIHYDROCHLORIDE
buclizine hydrochloride
Piperazine, 1- (p-tert-butylbenzyl)-4-(p-chloro-α-phenylbenzyl)-, dihydrochloride
buclizine dihydrochloride
Longifene
Piperazine, 1-[(4-chlorophenyl)phenylmethyl]-4-[[4-(1,1-dimethylethyl)phenyl]methyl]-, hydrochloride (1:2)
1-(p-tert-Butylbenzyl)-4-(p-chloro-α-phenylbenzyl)piperazine dihydrochloride
Piperazine, 1-(p-tert-butylbenzyl)-4-(p-chloro-α-phenylbenzyl)-, dihydrochloride

Chemical & Physical Properties

[ Boiling Point ]:
520.1ºC at 760 mmHg

[ Melting Point ]:
230-240ºC

[ Molecular Formula ]:
C28H35Cl3N2

[ Molecular Weight ]:
505.950

[ Flash Point ]:
268.3ºC

[ Exact Mass ]:
504.186584

[ PSA ]:
6.48000

[ LogP ]:
8.02450

[ Vapour Pressure ]:
6.44E-11mmHg at 25°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TL0280000
CHEMICAL NAME :
Piperazine, 1-(p-tert-butylbenzyl)-4-(p-chloro-alpha-phenylbenzyl )-, dihydrochloride
CAS REGISTRY NUMBER :
129-74-8
LAST UPDATED :
199701
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C28-H33-Cl-N2.2Cl-H
MOLECULAR WEIGHT :
506.00
WISWESSER LINE NOTATION :
T6N DNTJ AYR&R DG& D1R DX1&1&1 &GH 2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2100 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Lungs, Thorax, or Respiration - other changes
REFERENCE :
JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 43,653,1954
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
430 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Lungs, Thorax, or Respiration - other changes
REFERENCE :
JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 43,653,1954 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
360 mg/kg
SEX/DURATION :
female 10-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
AJOGAH American Journal of Obstetrics and Gynecology. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1920- Volume(issue)/page/year: 95,109,1966

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds

  • Benzylhydrazine dihydrochloride
  • Quinpirole dihydrochloride
  • A2764 dihydrochloride
  • Cyclobutylhydrazine dihydrochloride
  • Furosine dihydrochloride
  • benzidine dihydrochloride
  • (2R,2'R,3R,3'R,4R,4'R,5S,5'S)-6,6'-((2-Aminoethyl)azanediyl)bis(hexane-1,2,3,4,5-pentaol)
  • Methyl 4-(4-cyclopropyl-1H-imidazol-1-yl)picolinate
  • 2-Chloro-4-(2-fluorophenyl)-6-phenyl-1,3,5-triazine
  • N-[(1S)-1-carboxy-3-{[(1S)-1-carboxy-2-(1H-imidazol-5-yl)ethyl]amino}propyl]-L-glutamic acid
  • 2-Methoxy-4-[4-methyl-5-(4-piperazin-1-ylphenyl)pyridin-3-yl]benzamide
  • 3-(cyclopentylmethyl)-6-hydroxy-1H-indazole-5-carboxylic acid
  • tert-butyl 2-[5-[6-(trifluoromethylsulfonyloxy)naphthalen-2-yl]-1H-imidazol-2-yl]pyrrolidine-1-carboxylate
  • 8-[[4-(4-methoxyphenyl)piperazin-1-yl]methyl]-1,3-dimethyl-7-[(E)-3-phenylprop-2-enyl]-5H-purin-7-ium-2,6-dione
  • (4AS,8aS)-octahydro-1H-pyrido[3,4-b][1,4]oxazine
  • 1-(4-formyl-2-hydroxybenzoyl)pyrrolidin-3-yl N,N-dimethylcarbamate
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