Amizole

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Names

[ CAS No. ]:
129-89-5

[ Name ]:
Amizole

[Synonym ]:
Sulphamipyrin
Pyrazogin
(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-ylamino)-methansulfonsaeure,Natriumsalz
(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-ylamino)-methanesulfonic acid,sodium salt
N-(2,3-Dimethyl-5-oxo-1-phenyl-3-pyrazolin-4-yl)aminomethansulfonsaeure natriumsalz
Melaminsulfon
Amizole
SULFAMIPYRINE
1-Phenyl-2,3-dimethyl-4-amino-5-pyrazolon-N-methanesulfonsaeuren natrium [German]
Amizole (pharmaceutical)
Sulfamidopyrin-Natrium
Methanesulfonic acid,(antipyrinylamino)-,monosodium salt

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₂H₁₄N₃NaO₄S

[ Molecular Weight ]:
319.31200

[ Exact Mass ]:
319.06000

[ PSA ]:
104.54000

[ LogP ]:
1.55280

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: PB1280000

CHEMICAL NAME :: Methanesulfonic acid, (antipyrinylamino)-, monosodium salt

CAS REGISTRY NUMBER :: 129-89-5

LAST UPDATED :: 199512

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C12-H15-N3-O4-S.Na

MOLECULAR WEIGHT :: 320.35

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 5,213,1955

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5 gm/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - excitement

REFERENCE :: HDTU** "Pharmakologische Prufung von Analgetika, Dissertation," Herrlen, G., Pharmakologischen Institut der Universitat Tubingen, Fed. Rep. Ger., 1933 Volume(issue)/page/year: -,-,1933

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 3500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 5,213,1955

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 4500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 5,213,1955

Precursor & DownStream

Precursor

Formaldehyde
4-Aminoantipyrine

DownStream

Related Compounds

5-Fluoro-6-(2,2,2-trifluoroacetamido)pyridine-3-carboxylic acid
2-Fluoro-3-(2,2,2-trifluoroacetamido)pyridine-4-carboxylic acid
2-{5-[(2,2,2-trifluoroacetamido)methyl]-4H-1,2,4-triazol-3-yl}acetic acid
1-(1-Acetyl-1,2,3,6-tetrahydropyridin-4-yl)cyclopropane-1-carboxylic acid
Ethyl 2-amino-2-(2,3-dihydro-1-benzofuran-7-yl)acetate
2-[3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-2-methylpropanamido]-5-methylbenzoic acid
rac-benzyl N-[(1R,2S)-2-hydroxycyclobutyl]carbamate
(2S)-4-[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-4-methanesulfonylbutanamido]-2-hydroxybutanoic acid
rac-(2R,3S)-3-[3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)hexanamido]oxolane-2-carboxylic acid
Methyl 4-[(1,3-benzoxazol-2-yl)amino]butanoate

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