1,8-Naphtholactam
Suppliers
Names
[ CAS No. ]:
130-00-7
[ Name ]:
1,8-Naphtholactam
[Synonym ]:
1,8-Naphtholactam
Benz[cd]indol-2(1H)-one
MFCD00009748
Naphthostyril
Benzo[cd]indol-2(1H)-one
EINECS 204-973-4
1H-benzo[cd]indol-2-one
Chemical & Physical Properties
[ Density]:
1.3±0.1 g/cm3
[ Boiling Point ]:
234.7±7.0 °C at 760 mmHg
[ Melting Point ]:
173-178 °C(lit.)
[ Molecular Formula ]:
C11H7NO
[ Molecular Weight ]:
169.179
[ Flash Point ]:
128.9±3.1 °C
[ Exact Mass ]:
169.052765
[ PSA ]:
32.86000
[ LogP ]:
1.96
[ Vapour Pressure ]:
0.1±0.5 mmHg at 25°C
[ Index of Refraction ]:
1.724
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- DE3202000
- CHEMICAL NAME :
- Benz(cd)indol-2(1H)-one
- CAS REGISTRY NUMBER :
- 130-00-7
- LAST UPDATED :
- 199709
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C11-H7-N-O
- MOLECULAR WEIGHT :
- 169.19
- WISWESSER LINE NOTATION :
- T566 1A L CMVJ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1 gm/kg
- TOXIC EFFECTS :
- Behavioral - ataxia
- REFERENCE :
- CCCCAK Collection of Czechoslovak Chemical Communications. (Academic Press Inc. Ltd., 24-28 Oval Rd., London NW1 7DX, UK) V.1- 1929- Volume(issue)/page/year: 50,1888,1985
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - species unspecified
- DOSE/DURATION :
- 2700 mg/kg
- TOXIC EFFECTS :
- Behavioral - altered sleep time (including change in righting reflex) Behavioral - somnolence (general depressed activity)
- REFERENCE :
- GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 51(1),82,1986 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 4200 mg/kg/14D-I
- TOXIC EFFECTS :
- Liver - liver function tests impaired Blood - changes in leukocyte (WBC) count Related to Chronic Data - death
- REFERENCE :
- GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 51(1),82,1986
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H302
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves
[ Hazard Codes ]:
Xn:Harmful;
[ Risk Phrases ]:
R22
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
2
[ RTECS ]:
DE3202000
[ HS Code ]:
2925190090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2933990090
[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
Articles
ACS Med. Chem. Lett. 1(7) , 355-359, (2010)
Mycobacterium protein tyrosine phosphatase B (mPTPB) is an essential virulence factor required for Mycobacterium tuberculosis (Mtb) survival in host macrophages. Consequently, mPTPB represents an exci...
Acta Crystallogr. C 68(Pt 1) , o1-6, (2012)
Weakly diffracting crystals of benz[cd]indol-2(1H)-one (naphtholactam), C(11)H(7)NO, were unsuitable for data collection by early photographic methods. However, a diffractometer data set collected at ...