1,8-Naphtholactam

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Names

[ CAS No. ]:
130-00-7

[ Name ]:
1,8-Naphtholactam

[Synonym ]:
1,8-Naphtholactam
Benz[cd]indol-2(1H)-one
MFCD00009748
Naphthostyril
Benzo[cd]indol-2(1H)-one
EINECS 204-973-4
1H-benzo[cd]indol-2-one

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
234.7±7.0 °C at 760 mmHg

[ Melting Point ]:
173-178 °C(lit.)

[ Molecular Formula ]:
C11H7NO

[ Molecular Weight ]:
169.179

[ Flash Point ]:
128.9±3.1 °C

[ Exact Mass ]:
169.052765

[ PSA ]:
32.86000

[ LogP ]:
1.96

[ Vapour Pressure ]:
0.1±0.5 mmHg at 25°C

[ Index of Refraction ]:
1.724

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DE3202000
CHEMICAL NAME :
Benz(cd)indol-2(1H)-one
CAS REGISTRY NUMBER :
130-00-7
LAST UPDATED :
199709
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C11-H7-N-O
MOLECULAR WEIGHT :
169.19
WISWESSER LINE NOTATION :
T566 1A L CMVJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1 gm/kg
TOXIC EFFECTS :
Behavioral - ataxia
REFERENCE :
CCCCAK Collection of Czechoslovak Chemical Communications. (Academic Press Inc. Ltd., 24-28 Oval Rd., London NW1 7DX, UK) V.1- 1929- Volume(issue)/page/year: 50,1888,1985
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - species unspecified
DOSE/DURATION :
2700 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex) Behavioral - somnolence (general depressed activity)
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 51(1),82,1986 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
4200 mg/kg/14D-I
TOXIC EFFECTS :
Liver - liver function tests impaired Blood - changes in leukocyte (WBC) count Related to Chronic Data - death
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 51(1),82,1986

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn:Harmful;

[ Risk Phrases ]:
R22

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
2

[ RTECS ]:
DE3202000

[ HS Code ]:
2925190090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 1,3-dioxo-2,3-dihydro-1H-phenalen-2-yl 4-methylbenzenesulfonate
  • 1,2-Dichlorobenzene
  • 1-Naphthylisocyanate
  • 1,8-Naphthalic anhydride
  • Benzyl alcohol
  • N-mesitylenesulfonyloxy-1,8-naphthalimide
  • 8,9-dihydro-7H-benzo[de]pyrrolo[1,2-a]quinoline-7,10(7aH)-dione
  • 3,4-dimethyl-2,3-dihydro-1,4-benzoxazine
  • 1H-Benz[de]isoquinoline-1,3(2H)-dione,2-hydroxy-
  • 8-Bromo-1-naphthoic acid

DownStream

  • 1-ethylbenz[cd]indol-2(1H)-one
  • naphthoic acid
  • 8-Bromo-1-naphthoic acid
  • 8-Iodo-1-Naphthoic Acid
  • 1,8-Naphthalenedicarboxylicacid
  • N-(2-morpholin-4-ylethyl)benzo[cd]indol-2-amine,dihydrochloride
  • N-(2-phenylethyl)benzo[cd]indol-2-amine,hydrochloride
  • 6,7,8,8a-tetrahydro-1H-benzo[cd]indol-2-one
  • 1-AMINO-8-NAPHTHOIC ACID
  • 1-methylbenzo[cd]indol-2-one

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Identification and characterization of novel inhibitors of mPTPB, an essential virulent phosphatase from Mycobacterium tuberculosis.

ACS Med. Chem. Lett. 1(7) , 355-359, (2010)

Mycobacterium protein tyrosine phosphatase B (mPTPB) is an essential virulence factor required for Mycobacterium tuberculosis (Mtb) survival in host macrophages. Consequently, mPTPB represents an exci...

Benz[cd]indol-2(1H)-one at 298 and 100 K.

Acta Crystallogr. C 68(Pt 1) , o1-6, (2012)

Weakly diffracting crystals of benz[cd]indol-2(1H)-one (naphtholactam), C(11)H(7)NO, were unsuitable for data collection by early photographic methods. However, a diffractometer data set collected at ...


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  • 2,2-Difluoro-3-[methyl(thiolan-3-yl)amino]propanoic acid
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