3-Chloropropyl isocyanate

Names

[ CAS No. ]:
13010-19-0

[ Name ]:
3-Chloropropyl isocyanate

[Synonym ]:
Propane, 1-chloro-3-isocyanato-
1-Chloro-3-isocyanatopropane
3-Chloropropyl isocyanate
MFCD00010384

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
156.0±23.0 °C at 760 mmHg

[ Molecular Formula ]:
C₄H₆ClNO

[ Molecular Weight ]:
119.549

[ Flash Point ]:
58.7±11.8 °C

[ Exact Mass ]:
119.013794

[ PSA ]:
29.43000

[ LogP ]:
1.82

[ Vapour Pressure ]:
3.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.460

MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302 + H312 + H332-H319-H335

[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xn:Harmful;

[ Risk Phrases ]:
R20/21/22

[ Safety Phrases ]:
S23-S26-S27-S28-S36/37/39-S36/37

[ RIDADR ]:
UN 2206 6.1/PG 3

[ WGK Germany ]:
3

[ Packaging Group ]:
II

[ Hazard Class ]:
6.1

[ HS Code ]:
2929109000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

4-Chlorobutyryl chloride
Carbamic acid,(3-chloropropyl)-, ethyl ester (6CI,9CI)
phosgene
1-Chloronaphthalene
3-Methoxypropylamine
Toluene

DownStream

Urea,N,N'-bis(3-chloropropyl)-
(2-cyanophenyl) N-(3-chloropropyl)carbamate
1-[3-(2-oxo-1,3-diazinan-1-yl)phenyl]-1,3-diazinan-2-one

Customs

[ HS Code ]: 2929109000

[ Summary ]:
2929109000. other isocyanates. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Proline-linked nitrosoureas as prolidase-convertible prodrugs in human breast cancer cells.

Pharmacol. Rep. 60(2) , 171-82, (2008)

A number of novel proline-linked nitrosoureas (1-4) were synthesized and examined for cytotoxicity and influence on DNA and collagen biosynthesis in MDA-MB-231 and MCF-7 human breast cancer cells. Eva...

Imidazo [1', 2': 3, 4] pyrimido [6, 1-a] isoquinoline and Pyrimido [1', 2': 3, 4] pyrimido [6, 1-a] isoquinoline Ring Systems by Tandem Cyclization. Fülöp F, et al.

Synthesis 1995(07) , 863-67, (1995)

One-pot Syntheses of Fused Quinazolines by Reaction of N-(2-Cyanophenyl) chloromethanimidoyl Chloride. I. A New Synthesis of 1, 3-Oxazolo-and 1, 3-Oxazino [2, 3-b] quinazolines. Divišová H, et al.

Molecules 5(10) , 1166-74, (2000)

3-chloropropyl-2-furfurylsulfide
(3-chloropropyl)pentamethyldisiloxane
(3-chloropropyl)-ethoxy-dichlorosilane
3-chloropropyl 3,4,5-trimethoxybenzoate
3-chloropropyl(triethyl)silane
(3-chloropropyl)cyclohexane
1-(3,5-Dimethoxyphenyl)-3-[1-(oxan-4-yl)pyrrolidin-3-yl]urea
1-[(Thiophen-2-yl)methyl]-3-{[1-(thiophen-3-yl)cyclopropyl]methyl}urea
3-(2-Bromophenyl)-1-(3-{octahydrocyclopenta[c]pyrrol-2-yl}azetidin-1-yl)propan-1-one
3-{octahydrocyclopenta[c]pyrrol-2-yl}-N-[4-(trifluoromethyl)phenyl]azetidine-1-carboxamide
N-(4-Bromo-2-fluorophenyl)-6-(oxan-4-yl)pyrimidine-4-carboxamide
8-Methoxy-3-[4-(thian-4-yl)-1,4-diazepane-1-carbonyl]chromen-2-one
4-[5-(6-cyclopropylpyridazin-3-yl)-octahydropyrrolo[3,4-c]pyrrole-2-carbonyl]-N,N-dimethylaniline
4-Methyl-2-[5-(4-phenyloxane-4-carbonyl)-octahydropyrrolo[3,4-c]pyrrol-2-yl]pyrimidine
7-Fluoro-2-methyl-3-({1-[(pyridin-3-yl)methyl]piperidin-4-yl}methyl)-3,4-dihydroquinazolin-4-one
2-[5-(2-Fluorobenzenesulfonyl)-octahydropyrrolo[3,4-c]pyrrol-2-yl]-5-(trifluoromethyl)pyridine

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