Latanoprost

Suppliers

Names

[ Name ]:
Latanoprost

[Synonym ]:
13,14-Dihydro-17-phenyl-18,19,20-trinor-PGF2a-isopropyl Ester
5-Heptenoic acid, 7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]-, 1-methylethyl ester, (5Z)-
Lata prostaglandin
Xalatan
1-Methylethyl-(5Z)-7-{(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl}hept-5-enoat
Isopropyl (5Z)-7-{(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl}hept-5-enoate
phxa41
Latanoprost
MFCD00216074
(5Z)-7-{(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phénylpentyl]cyclopentyl}hept-5-énoate de 1-méthyléthyle
xa41
Propan-2-yl-(5Z)-7-{(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl}hept-5-enoat
LATANAPROST
propan-2-yl (5Z)-7-{(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl}hept-5-enoate
Xalata
[1R-[1a(Z),2b(R*),3a,5a]]-7-[3,5-Dihydroxy-2-(3-hydroxy-5-phenylpentyl)cyclopentyl]-5-heptenoic Acid 1-Methylethyl Ester
Isopropyl (5Z)-7-{(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl}-5-heptenoate
1-methylethyl (5Z)-7-{(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl}hept-5-enoate
Isopropyl (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]-5-heptenoate

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
583.8±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₆H₄₀O₅

[ Molecular Weight ]:
432.593

[ Flash Point ]:
188.3±23.6 °C

[ Exact Mass ]:
432.287567

[ PSA ]:
86.99000

[ LogP ]:
3.65

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.538

[ Storage condition ]:
−20°C

[ Water Solubility ]:
DMSO: freely soluble

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
MJ9669550

[ HS Code ]:
2937500000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

2-Iodopropane
LatanoprostAcid
Isopropanol
isopropyl (Z)-7-((1R,2R,3R,5S)-2-((3R)-5-phenyl-3-((tetrahydro-2H-pyran-2-yl)oxy)pentyl)-3,5-bis((tetrahydro-2H-pyran-2-yl)oxy)cyclopentyl)hept-5-enoate
2-Bromopropane

DownStream

Customs

[ HS Code ]: 2937500000

Articles

Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

J. Sci. Ind. Res. 65(10) , 808, (2006)

Drug-induced liver injury (DILI) is a significant concern in drug development due to the poor concordance between preclinical and clinical findings of liver toxicity. We hypothesized that the DILI typ...

Effects of K-115, a rho-kinase inhibitor, on aqueous humor dynamics in rabbits.

Curr. Eye Res. 39(8) , 813-22, (2014)

To evaluate the topical instillation of K-115, a selective Rho-associated coiled coil-containing protein kinase (ROCK) inhibitor, on intraocular pressure (IOP), ocular distribution, and aqueous humor ...

COX-2 inhibition improves retinal function in rats' ischemic eyes.

J. Ocul. Pharmacol. Ther. 30(8) , 634-41, (2014)

Retinal ischemia is a relatively simple model for studies in pharmacological neuroprotective intervention. The role of cyclooxygenase (COX) enzymes in ischemic insult has been variously shown to eithe...

LatanoprostAcid
LatanoprostLactol
trans Latanoprost
15(S)-Latanoprost
15-Ketolatanoprost
Latanoprost-timolol
Olafertinib maleate
4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
(E)-1-(1-(3-(thiophen-2-yl)acryloyl)azetidin-3-yl)pyrrolidine-2,5-dione
1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
3-Iodo-2-methylpyrazolo[1,5-a]pyrimidine
1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
4-(Difluoromethyl)-2-fluoro-3-methoxy-6-nitropyridine
(4-Methyl-tetrahydro-furan-2-yl)-methanol
N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide