4,4-Dimethyldihydro-2,3-furandione

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Names

[ Name ]:
4,4-Dimethyldihydro-2,3-furandione

[Synonym ]:
4,4-dimethyloxolane-2,3-dione
ketopantolactone
4,4-Dimethyldihydro-2,3-furandione
2,3-Furandione,dihydro-4,4-dimethyl
MFCD00012331
4,4-dimethyl-2,3(5H)-furandione
Keto-pantoyllactone
dihydro-4,4-dimethylfuran-2,3-dione
4,4-dimethyltetrahydrofuran-2,3-dione
Dihydro-4,4-dimethyl-2,3-Furandione
4,4-Dimethyldihydrofuran-2,3-dione
2-oxopantoyl lactone
2,3-Furandione, dihydro-4,4-dimethyl-
EINECS 235-891-7
2-dehydropantoyl lactone

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
260.5±7.0 °C at 760 mmHg

[ Melting Point ]:
67-69ºC(lit.)

[ Molecular Formula ]:
C₆H₈O₃

[ Molecular Weight ]:
128.126

[ Flash Point ]:
122.8±15.4 °C

[ Exact Mass ]:
128.047348

[ PSA ]:
43.37000

[ LogP ]:
-0.27

[ Vapour Pressure ]:
0.0±0.5 mmHg at 25°C

[ Index of Refraction ]:
1.446

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2932190090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DL-Pantolactone
Formaldehyde
Sodium 3-methyl-2-oxobutanoate
Isobutyraldehyde
Diethyloxalate
4-hydroxy-3,3-dimethyl-2-oxobutanoic acid
lead tetraacetate
benzene

DownStream

(±)-methyl mandelate
DL-Pantolactone
Methyl (2S)-hydroxy(phenyl)acetate
(R)-methyl mandelate
D-(-)-Pantolactone
Ethyl lactate
(−)-Ethyl L-lactate
(R)-ethyl 2-hydroxypropanoate
1,1-Dimethoxypropan-2-ol
3-methylnaphthalene-1,2-dione

Customs

[ HS Code ]: 2932190090

[ Summary ]:
2932190090 other compounds containing an unfused furan ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

Articles

Effect of cyclodextrin on improvement of enantioselectivity in the reduction of ketopantolactone with baker's yeast.

Bioorg. Med. Chem. 2(6) , 433-7, (1994)

Addition of beta-cyclodextrin improves enantioselectivity dramatically in the reduction of ketopantolactone mediated by baker's yeast. It has been found that the selectivity increases with the decreas...

Gene cloning and overexpression of two conjugated polyketone reductases, novel aldo-keto reductase family enzymes, of Candida parapsilosis.

Appl. Microbiol. Biotechnol. 64(3) , 359-66, (2004)

The genes encoding two conjugated polyketone reductases (CPR-C1, CPR-C2) of Candida parapsilosis IFO 0708 were cloned and sequenced. The genes encoded a total of 304 and 307 amino acid residues for CP...

LplR, a repressor belonging to the TetR family, regulates expression of the L-pantoyl lactone dehydrogenase gene in Rhodococcus erythropolis.

Appl. Environ. Microbiol. 78(22) , 7923-30, (2012)

The L-pantoyl lactone (L-PL) dehydrogenase (LPLDH) gene (lpldh) has been cloned from Rhodococcus erythropolis AKU2103, and addition of 1,2-propanediol (1,2-PD) was shown to be required for lpldh expre...

2,3-Furandione, dihydro-5-hydroxy-4,4-dimethyl-, 3-oxime (9CI)
dihydro-4,4-dimethyl-5-(1-methylethyl)-2,3-furandione
3-(tert-butyldimethylsilanyloxy)-4,4-dimethyldihydro-2(3H)-furan-2-one
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(S)-(+)-Pantolactone
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2,2-dimethyl-N-{1-[6-(trifluoromethyl)pyrimidin-4-yl]azetidin-3-yl}propanamide
2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
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1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
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4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
tert-Butyl-DL-alanine