Nitidine chloride
Suppliers
Names
[ CAS No. ]:
13063-04-2
[ Name ]:
Nitidine chloride
[Synonym ]:
2,3-Dimethoxy-12-methyl-[1,3]benzodioxolo[5,6-c]phenanthridinium chloride
[1,3]Benzodioxolo[5,6-c]phenanthridinium, 2,3-dimethoxy-12-methyl-, chloride (1:1)
2,3-Dimethoxy-12-methyl[1,3]benzodioxolo[5,6-c]phenanthridin-12-ium chloride
Nitidine chloride
2,3-dimethoxy-12-methyl-[1,3]benzodioxolo[5,6-c]phenanthridin-12-ium,chloride
Chemical & Physical Properties
[ Density]:
1.35g/cm3
[ Boiling Point ]:
619ºC at 760 mmHg
[ Melting Point ]:
281-282ºC
[ Molecular Formula ]:
C21H18ClNO4
[ Molecular Weight ]:
383.825
[ Flash Point ]:
189.4ºC
[ Exact Mass ]:
383.092438
[ PSA ]:
40.80000
[ LogP ]:
3.71660
[ Appearance of Characters ]:
white to beige
[ Vapour Pressure ]:
3.01E-15mmHg at 25°C
[ Index of Refraction ]:
1.696
[ Storage condition ]:
?20°C
[ Water Solubility ]:
DMSO: soluble1mg/mL, clear (warmed)
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- DF4935500
- CHEMICAL NAME :
- (1,3)-Benzodioxolo(5,6-c)phenanthridinium, 2,3-dimethoxy-12-methyl-, chloride
- CAS REGISTRY NUMBER :
- 13063-04-2
- LAST UPDATED :
- 199410
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C21-H18-N-O4.Cl
- MOLECULAR WEIGHT :
- 383.85
- WISWESSER LINE NOTATION :
- T G5 E6 B666 HO JO OK IHJ O1 SO1 TO1 &G
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 98980 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
MUTATION DATA
- TYPE OF TEST :
- Mutation in microorganisms
- TEST SYSTEM :
- Bacteria - Salmonella typhimurium
- DOSE/DURATION :
- 40 ug/plate
- REFERENCE :
- JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 66,1781,1977
Safety Information
[ Safety Phrases ]:
24/25
[ RIDADR ]:
NONH for all modes of transport
[ RTECS ]:
DF4935500
[ HS Code ]:
2933990090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2933990090
[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
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Two quinoline alkaloids, (-)-R-geilbalansine (1) and hyemaline (2), as well as aromatic amide, N-[2-(3,4-dimethoxyphenyl)-2-methoxyethyl)-2-methoxyethyl]benzamide (O-methylbalsamide) (3), were isolate...
J. Pharm. Pharmacol. 50(11) , 1307-15, (1998)
The quaternary benzo[c]phenanthridines fagaronine, nitidine and O-methylfagaronine have been reviewed as potential antitumour and antiviral agents. Their mode of action has not been established, but t...