1-Nitroso-2-naphthol

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Names

[ CAS No. ]:
131-91-9

[ Name ]:
1-Nitroso-2-naphthol

[Synonym ]:
Nitroso-2-Naphthol
Zelen moridlova 4
ortho-hydroxynitrosonaphthalene
1-NITROSO-2-NAPTHOL
1-Nitroso-2-naphthol
1-nitroso-2-naphtho
1-nitroso-2-hydroxy-naphthalene
1-Nitroso-2-naphthalenol
1-Nitroso-2-naftol
2-hydroxy-1-nitrosonaphthalene
Nitroso-β-naphthol
EINECS 205-043-0
2-Naphthalenol, 1-nitroso-
MFCD00003884

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
357.6±25.0 °C at 760 mmHg

[ Melting Point ]:
106-108 °C (dec.)(lit.)

[ Molecular Formula ]:
C10H7NO2

[ Molecular Weight ]:
173.168

[ Flash Point ]:
170.1±23.2 °C

[ Exact Mass ]:
173.047684

[ PSA ]:
49.66000

[ LogP ]:
2.42

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.630

[ Water Solubility ]:
insoluble

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
QL4725000
CHEMICAL NAME :
2-Naphthol, 1-nitroso-
CAS REGISTRY NUMBER :
131-91-9
BEILSTEIN REFERENCE NO. :
0776947
LAST UPDATED :
199710
DATA ITEMS CITED :
8
MOLECULAR FORMULA :
C10-H7-N-O2
MOLECULAR WEIGHT :
173.18
WISWESSER LINE NOTATION :
L66J BNO CQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :
DNA repair
TEST SYSTEM :
Bacteria - Bacillus subtilis
DOSE/DURATION :
10 mmol/L
REFERENCE :
JNSVA5 Journal of Nutritional Science and Vitaminology. (Business Center for Academic Soc. Japan, 2-4-16 Yayoi, Bunkyo-ku, Tokyo 113, Japan) V.19- 1973- Volume(issue)/page/year: 25,317,1979 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 82063 No. of Facilities: 75 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 1215 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 82063 No. of Facilities: 20 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 799 (estimated) No. of Female Employees: 655 (estimated)

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn:Harmful;

[ Risk Phrases ]:
R33

[ Safety Phrases ]:
S26-S36-S45

[ RIDADR ]:
UN3077

[ WGK Germany ]:
3

[ RTECS ]:
QL4725000

[ Packaging Group ]:
III

[ Hazard Class ]:
9

[ HS Code ]:
29089000

Synthetic Route

Precursor & DownStream

Precursor

  • 2-Naphthol
  • 1,1'-METHYLENEDI-2-NAPHTHOL
  • nitrous acid
  • Water
  • nitric acid

DownStream

  • Phthalide-3-Acetic Acid
  • 2-[(E)-2-Carboxyvinyl]benzoic acid
  • 1-Nitro-2-naphthol
  • 1,6-dinitronaphthalen-2-ol
  • 1,2-NAPHTHOQUINONE
  • 2-(3-oxo-1,2-dihydroisoindol-1-yl)acetic acid
  • 10-methylbenzo[a]phenoxazin-5-one
  • leucoline
  • Isoquinoline
  • Indene

Customs

[ HS Code ]: 2908999090

[ Summary ]:
2908999090 halogenated, sulphonated, nitrated or nitrosated derivatives of phenols or phenol-alcohols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

Articles

Improved fluorometric determination of acetaminophen and its conjugates with 1-nitroso-2-naphthol in whole blood and urine.

Chem. Pharm. Bull. 30(1) , 358-61, (1982)

Determination of urinary homovanillic acid using the nitrosonaphthol reaction.

Am. J. Clin. Pathol. 87(5) , 644-8, (1987)

Determination of urinary homovanillic acid (HVA) is an important analysis to establish the diagnosis and prognosis of neuroblastoma. A method is presented for the determination of this metabolite of d...

Improved quantitation for urinary 5-hydroxyindole acetate using the nitrosonaphthol reaction.

Clin. Biochem. 17(1) , 37-8, (1984)


More Articles


Related Compounds

  • 1-nitroso-2-naphthol
  • 3-Brom-1-nitroso-2-naphthol
  • 6-Brom-1-nitroso-2-naphthol
  • 3-Ethoxy-1-nitroso-2-naphthol
  • 4-Ethoxy-1-nitroso-2-naphthol
  • 7-Ethoxy-1-nitroso-2-naphthol
  • 5-[Methyl(propan-2-yl)amino]pent-2-enoic acid
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 2-cyclopropyl-3-{2-[({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)methyl]butanoyl}-1,3-thiazolidine-4-carboxylic acid
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • 1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl 2-(2-oxo-3,4-dihydro-2H-1,3-benzoxazin-3-yl)acetate
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • (2R,3R)-3-bromo-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)butanoic acid