(4S,4aR,7S,7aR,12bS,13S)-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7,9,13-triol

Names

[ Name ]:
(4S,4aR,7S,7aR,12bS,13S)-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7,9,13-triol

[Synonym ]:
10-Hydroxymorphine

Chemical & Physical Properties

[ Density]:
1.54g/cm3

[ Boiling Point ]:
537.2ºC at 760mmHg

[ Molecular Formula ]:
C₁₇H₁₉NO₄

[ Molecular Weight ]:
301.33700

[ Flash Point ]:
278.7ºC

[ Exact Mass ]:
301.13100

[ PSA ]:
73.16000

[ LogP ]:
0.62690

[ Vapour Pressure ]:
2.27E-12mmHg at 25°C

[ Index of Refraction ]:
1.747

Safety Information

[ Symbol ]:

GHS02, GHS06, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H225-H301 + H311 + H331-H370

[ Precautionary Statements ]:
P210-P260-P280-P301 + P310-P311

[ RIDADR ]:
UN1230 - class 3 - PG 2 - Methanol, solution

Precursor & DownStream

Precursor

DownStream

Articles

Impurities in a morphine sulfate drug product identified as 5-(hydroxymethyl)-2-furfural, 10-hydroxymorphine and 10-oxomorphine.

J. Pharm. Sci. 92(3) , 485-93, (2003)

Stability testing of morphine sulfate formulated with nonpareil sugar seeds (consisting of sucrose and starch) and fumaric acid revealed the formation of the three impurities 5-(hydroxymethyl)-2-furfu...

Morphine impurity with opioid activity is identified as 10 alpha-hydroxymorphine.

Pharm. Res. 7(11) , 1205-7, (1990)

Separation of morphine and its oxidation products by capillary zone electrophoresis.

J. Pharm. Biomed. Anal. 20(1-2) , 179-83, (1999)

Separation of morphine and its oxidation products (10-S-hydroxymorphine, pseudomorphine and morphine N-oxide) by capillary zone electrophoresis in Tris-borate buffer in the presence of cyclodextrins w...