Arbidol HCl

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Names

[ CAS No. ]:
131707-23-8

[ Name ]:
Arbidol HCl

[Synonym ]:
1-methyl-2-phenylthiomethyl-3-carbethoxy-4-dimetylaminomethyl-5-hydroxy-6-bromoindole hydrogen chloride
Arbidol Hydrochloride
6-Bromo-4-((dimethylamino)methyl)-5-hydroxy-1-methyl-2-((phenylthio)methyl)-1H-indole-3-carboxylic Acid Ethyl Ester Moonohydrochloride
Ethyl 6-bromo-4-[(dimethylamino)methyl]-5-hydroxy-1-methyl-2-[(phenylsulfanyl)methyl]-1H-indole-3-carboxylate hydrochloride (1:1)
1-methyl-2-phenylthiomethyl-3-carbethoxy-4-dimethylaminomethyl-5-oxy-6-bromindol hydrochloride
Arbidol Hydrochloride Hydrate
arbidol hydrogen chloride
1H-Indole-3-carboxylic acid, 6-bromo-4-[(dimethylamino)methyl]-5-hydroxy-1-methyl-2-[(phenylthio)methyl]-, ethyl ester, hydrochloride (1:1)
umifenovir hydrogen chloride
Arbidol HCl
MFCD00333871
Arbidol
umifenovir hydrochloride
Arbidol (hydrochloride)

Chemical & Physical Properties

[ Boiling Point ]:
591.8ºC at 760 mmHg

[ Melting Point ]:
133-137ºC

[ Molecular Formula ]:
C22H26BrClN2O3S

[ Molecular Weight ]:
513.875

[ Flash Point ]:
311.7℃

[ Exact Mass ]:
512.053589

[ PSA ]:
80.00000

[ LogP ]:
5.97900

[ Vapour Pressure ]:
1.34E-14mmHg at 25°C

[ Storage condition ]:
Hygroscopic, Refrigerator, Under Inert Atmosphere

[ Stability ]:
Hygroscopic

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NL5998075
CHEMICAL NAME :
1H-Indole-3-carboxylic acid, 6-bromo-4-((dimethylamino)methyl)-5-hydroxy-1-methyl- 2- ((phenylthio)methyl)-, ethyl ester, monohydrochloride, hydrate
CAS REGISTRY NUMBER :
131707-23-8
LAST UPDATED :
199312
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C22-H25-Br-N2-O3-S.Cl-H.H2-O
MOLECULAR WEIGHT :
531.94

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>3 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 17,1079,1992
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
340 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 17,1079,1992
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
>3 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 17,1079,1992

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319

[ Precautionary Statements ]:
P305 + P351 + P338

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
36/38

[ Safety Phrases ]:
26

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2933990090

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

[Potentiation of NO-dependent activation of soluble guanylyl cyclase by 5-nitroisatin and antiviral preparatation arbidol].

Biomed. Khim. 59(3) , 295-304, (2013)

Isatin (indole-dione) is an endogenous indole that exibits a wide range of biological and physiological activity. The influence of isatin derivatives 5-nitroisatin and arbidol (an antiviral preparatat...

Arbidol exhibits strong inhibition towards UDP-glucuronosyltransferase (UGT) 1A9 and 2B7.

Pharmazie 68(12) , 945-50, (2013)

The aim of the present study was to investigate arbidol's inhibition towards UDP-glucuronosyltransferase (UGT) 1A9 and 2B7. The nonspecific probe substrate 4-methylumbelliferone (4-MU) and recombinant...

Pharmacokinetics, metabolism, and excretion of the antiviral drug arbidol in humans.

Antimicrob. Agents Chemother. 57(4) , 1743-55, (2013)

Arbidol is a broad-spectrum antiviral drug that is used clinically to treat influenza. In this study, the pharmacokinetics, metabolism, and excretion of arbidol were investigated in healthy male Chine...


More Articles

Related Compounds

  • arbidol hcl
  • Arbidol Sulfoxide
  • EPZ020411 HCl
  • Difelikefalin HCl
  • CPD3.1 HCl
  • Raloxifene HCl
  • (2-Methyl-1-phenylpropyl)(prop-2-en-1-yl)amine
  • Piperidine-4-carboxylic acid (3,4-dichloro-phenyl)-methyl-amide
  • (4S,5S)-5-(Hydroxymethyl)-4-methyl-3-(phenylmethyl)-2-oxazolidinone
  • 3-Heptylimidazolidine-2,4-dione
  • 7-(2-Methoxyethoxy)-N-[[6-(3-methyl-5-isothiazolyl)-1,2,4-triazolo[4,3-b]pyridazin-3-yl]methyl]-1,5-naphthyridin-4-amine
  • Ethyl 4-(2,6-dichloro-3-fluorophenyl)-2,4-dioxobutanoate
  • 1,1-Dimethylethyl 2-[3-(acetylthio)-1-oxopropyl]-2,3-dihydro-1H-isoindole-1-carboxylate
  • 10-Dimethylamino-9-methoxymethyl-1-methyl-tricyclo[7.3.1.0*2,7*]trideca-2,4,6-trien-4-ol
  • Benzyl-{3-[3-(3,4-dimethoxy-phenyl)-3-oxo-propyl]-phenyl}-dimethyl-ammonium; bromide
  • rel-(3S,4R)-3-[(1R)-1-Hydroxy-3-phenylpropyl]-4-(4-methoxyphenyl)-1-phenyl-2-azetidinone
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