Fmoc-Gln(Trt)-OH

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Names

[ CAS No. ]:
132327-80-1

[ Name ]:
Fmoc-Gln(Trt)-OH

[Synonym ]:
N-Fmoc-N'-trityl-L-glutamine
Fmoc-Gln(Tr)-OH
N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-trityl-L-glutamine
MFCD00077056
(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-5-oxo-5-(tritylamino)pentanoic acid
Nalpha-Fmoc-Ndelta-Trityl-L-Glutamine
fmoc-Gln(Trt)-OH
Fmoc-L-Gln(Trt)-OH
N-Fmoc-N5-trityl-L-Glutamine
L-Glutamine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-N-(triphenylmethyl)-
N|A-Fmoc-N|A-trityl-L-glutamine
Fmoc-Gln(N-Trt)-OH

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
873.5±65.0 °C at 760 mmHg

[ Melting Point ]:
165-172 °C

[ Molecular Formula ]:
C39H34N2O5

[ Molecular Weight ]:
610.70

[ Flash Point ]:
482.1±34.3 °C

[ Exact Mass ]:
610.246765

[ PSA ]:
104.73000

[ LogP ]:
8.09

[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.636

[ Storage condition ]:
2-8°C

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H317-H413

[ Precautionary Statements ]:
P280

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Tritanol
  • Fmoc-Gln-OH
  • Z-Gln-OH
  • Z-Gln(Trt)-OH
  • L-Glutamine
  • Fmoc-Osu
  • H-Gln(Trt)-OH

DownStream

  • Fmoc-β-HomoGln(trt)-OH
  • Fmoc-Gln-OH
  • H-Gln(Trt)-OH
  • Fmoc-Gln(Trt)-OPfp

Articles

Chemical synthesis of a polypeptide backbone derived from the primary sequence of the cancer protein NY-ESO-1 enabled by kinetically controlled ligation and pseudoprolines.

Biopolymers 104 , 116-27, (2015)

The cancer protein NY-ESO-1 has been shown to be one of the most promising vaccine candidates although little is known about its cellular function. Using a chemical protein strategy, the 180 amino aci...

Correlations of amyloid-β concentrations between CSF and plasma in acute Alzheimer mouse model.

Sci. Rep. 4 , 6777, (2014)

Amyloid-β (Aβ) is one of the few neuropathological biomarkers associated with transporters of the blood-brain barrier (BBB). Despite the well-characterized clinical indication of decreasing Aβ levels ...

Inhibition of Kallikrein-Related Peptidases 7 and 5 by Grafting Serpin Reactive-Center Loop Sequences onto Sunflower Trypsin Inhibitor-1 (SFTI-1).

ChemBioChem. 17 , 719-26, (2016)

Serpin proteins irreversibly inhibit serine proteases, but only a small part of the serpin reactive-center loop (RCL) is responsible for the initial protein-protein interaction (PPI). To develop pepti...


More Articles

Related Compounds

  • Fmoc-Gln(Trt)-OH
  • Boc-Ser(Fmoc-Gln(Trt))-OH
  • Fmoc-Gln(Trt)-Thr(psi(Me,Me)pro)-OH
  • Fmoc-Gln(Trt)-Ser(psi(Me,Me)pro)-OH
  • Fmoc-Gln(Trt)-OL
  • Fmoc-Gln(Trt)-OPfp
  • 2-{1-[(tert-butoxy)carbonyl]piperidin-4-yl}-2-{[(1S)-2,2-dimethylcyclopropyl]({[(9H-fluoren-9-yl)methoxy]carbonyl})amino}propanoic acid
  • 1-[(tert-butoxy)carbonyl]-4-({[(9H-fluoren-9-yl)methoxy]carbonyl}(3-fluoro-3-methylbutyl)amino)-2,2-dimethylpiperidine-4-carboxylic acid
  • Ethyl 1-{bicyclo[3.2.0]heptan-2-yl}piperidine-4-carboxylate
  • tert-butyl 5-{7-oxabicyclo[2.2.1]heptan-2-yl}-1H-1,2,3-triazole-4-carboxylate
  • 5-(Difluoromethoxy)-2-isopropylpyrimidin-4-amine
  • Methyl 2-{[1,2,4]triazolo[4,3-a]pyridin-6-yl}propanoate
  • 6-Amino-5-methoxy-N,N-dimethyl-3-pyridinesulfonamide
  • 1-[4-Methyl-3-(trifluoromethyl)phenyl]propan-2-one
  • 2,2-Difluoro-1-[5-(trifluoromethyl)pyridin-2-yl]ethan-1-one
  • 5-[4-(Trifluoromethyl)phenyl]hex-3-en-2-one
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