Olanzapine

Suppliers

Names

[ CAS No. ]:
132539-06-1

[ Name ]:
Olanzapine

[Synonym ]:
10H-thieno2,3-b1,5benzodiazepine, 2-methyl-4-(4-methyl-1-piperazinyl)-
Olanzapine
2-Methyl-4-(4-methyl-1-piperazinyl)- 10H-thieno[2,3-b][1,5]benzodiazepine
2-Methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3-b][1,5]benzodiazepine
2-Methyl-4-(4-methylpiperazin-1-yl)-10H-benzo[b]thieno[2,3-e][1,4]diazepine
2-méthyl-4-(4-méthylpipérazin-1-yl)-10H-thiéno[2,3-b][1,5]benzodiazépine
2-Methyl-4-(4-methyl-1-piperazinyl)- 10H-thieno[2,3-b][1,5]benzodiazepine LY-170053
Integrol
Oltal
Larmac
ZYPREXA
OLANZAPINE FORM I
2-Methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5]benzodiazepine
2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno2,3-b1,5benzodiazepine
lanzac
Oleanz
10H-Thieno[2,3-b][1,5]benzodiazepine, 2-methyl-4-(4-methyl-1-piperazinyl)-
2-Methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3-b][1,5]benzodiazepin
Oliza
MFCD00866702
EINECS 200-835-2

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
476.0±55.0 °C at 760 mmHg

[ Melting Point ]:
195°C

[ Molecular Formula ]:
C17H20N4S

[ Molecular Weight ]:
312.432

[ Flash Point ]:
241.7±31.5 °C

[ Exact Mass ]:
312.140869

[ PSA ]:
59.11000

[ LogP ]:
2.18

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.709

[ Storage condition ]:
-20°C Freezer

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319

[ Precautionary Statements ]:
P305 + P351 + P338

[ Hazard Codes ]:
Xi,Xn,F

[ Risk Phrases ]:
36/38-36-20/21/22-11

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
UN 2811 6.1 / PGIII

[ WGK Germany ]:
3

[ HS Code ]:
2934999090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 2-Methyl-4-(1-piperazinyl)-10H-thienol[2,3-b][1,5]benzodiazepine
  • methyl iodide
  • Dimethyl sulfate
  • 3-THIOPHENECARBOXYLIC ACID-5-METHYL-2-{2-(NITROPHENYL)AMINO}METHYL ESTER
  • methylpiperazine
  • 4-AMINO-2-METHYL-10H-THIENO(2,3-B)(1,5)-BENZODIAZEPINE
  • 5-Methyl-2-[(2-nitrophenyl)amino]thiophene-3-carbonitrile
  • 2-(2-aminoanilino)-5-methylthiophene-3-carbonitrile

DownStream

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

The stress stability of olanzapine: studies of interactions with excipients in solid state pharmaceutical formulations.

Drug Dev. Ind. Pharm. 41(3) , 502-14, (2015)

Stress stability testing represents an important part of the drug development process. It is used as an important tool for the identification of degradation products and degradation pathways, as well ...

Simple and sensitive screening and quantitative determination of 88 psychoactive drugs and their metabolites in blood through LC–MS/MS: Application on postmortem samples

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 970 , 1-7, (2014)

• The introduction has been modified. • More references have been added to the text. • Limitations of the method have been discussed more in detail.

Olanzapine inhibits the proliferation and induces the differentiation of glioma stem-like cells through modulating the Wnt signaling pathway in vitro.

Eur. Rev. Med. Pharmacol. Sci. 19 , 2406-15, (2015)

Olanzapine, a D2/5-HT2 antagonist, is often used as an atypical antipsychotic drug in clinical. Previous research has found its new pharmacological influence on enhancing the differentiation of neural...


More Articles

Related Compounds

  • 1-tert-butyl-4-{1-[3-(4-chloro-3-methylphenoxy)-2-hydroxypropyl]-1H-benzimidazol-2-yl}pyrrolidin-2-one
  • 1-tert-butyl-4-{1-[3-(2,5-dimethylphenoxy)-2-hydroxypropyl]-1H-1,3-benzodiazol-2-yl}pyrrolidin-2-one
  • 1-(tert-butyl)-4-(1-(2-hydroxy-3-(o-tolyloxy)propyl)-1H-benzo[d]imidazol-2-yl)pyrrolidin-2-one
  • 1-tert-butyl-4-{1-[3-(2,6-dimethylphenoxy)-2-hydroxypropyl]-1H-1,3-benzodiazol-2-yl}pyrrolidin-2-one
  • 1-tert-butyl-4-{1-[3-(3,5-dimethylphenoxy)-2-hydroxypropyl]-1H-1,3-benzodiazol-2-yl}pyrrolidin-2-one
  • 1-Benzimidazolyl-3-(2,4-dimethylphenoxy)propan-2-ol
  • 1-(2-Ethylbenzimidazolyl)-3-(4-ethylphenoxy)propan-2-ol
  • 3-(3,4-Dimethylphenoxy)-1-(2-ethylbenzimidazolyl)propan-2-ol
  • 1-tert-butyl-4-{1-[3-(4-chloro-3,5-dimethylphenoxy)-2-hydroxypropyl]-1H-benzimidazol-2-yl}pyrrolidin-2-one
  • 1-(2-Cyclohexylbenzimidazolyl)-3-(4-methylphenoxy)propan-2-ol
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