Urea,N,N'-dimethyl-N'-nitroso-

Suppliers

Names

[ CAS No. ]:
13256-32-1

[ Name ]:
Urea,N,N'-dimethyl-N'-nitroso-

[Synonym ]:
N,N'-Dimethylnitrosourea
1,3 dimethyl 1 nitrosourea
N-nitroso-1,3-dimethylurea
Dimethylnitrosourea
1,3-Dimethylnitrosourea
N-nitroso-N,N'-dimethylurea
1,3-Dimethyl-N-nitrosourea
1,2-Dimethyl-1-nitrosourea
Nitrosodimethylurea
N,N'-Dimethyl-N-nitrosourea
N-Nitrosodimethylurea

Chemical & Physical Properties

[ Density]:
1.25g/cm3

[ Molecular Formula ]:
C3H7N3O2

[ Molecular Weight ]:
117.10700

[ Exact Mass ]:
117.05400

[ PSA ]:
61.77000

[ LogP ]:
0.32990

[ Index of Refraction ]:
1.505

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
YT0350000
CHEMICAL NAME :
Urea, 1,3-dimethyl-1-nitroso-
CAS REGISTRY NUMBER :
13256-32-1
BEILSTEIN REFERENCE NO. :
1756842
LAST UPDATED :
199612
DATA ITEMS CITED :
22
MOLECULAR FORMULA :
C3-H7-N3-O2
MOLECULAR WEIGHT :
117.13
WISWESSER LINE NOTATION :
ONN1&VM1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
280 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
280 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1300 mg/kg/65W-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Brain and Coverings - tumors Peripheral Nerve and Sensation - peripheral nerve tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
836 mg/kg/20W-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria Brain and Coverings - tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
660 mg/kg/66W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Brain and Coverings - tumors Peripheral Nerve and Sensation - peripheral nerve tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
720 mg/kg/9W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Blood - lymphoma, including Hodgkin's disease
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - hamster
DOSE/DURATION :
680 mg/kg/17W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors Skin and Appendages - tumors
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
56222 mg/kg/30W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Brain and Coverings - tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
DOSE :
20 mg/kg
SEX/DURATION :
female 10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - other developmental abnormalities
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Parenteral
DOSE :
10 mg/kg
SEX/DURATION :
female 13 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - musculoskeletal system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Parenteral
DOSE :
50 mg/kg
SEX/DURATION :
female 9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death
TYPE OF TEST :
DNA inhibition

MUTATION DATA

TYPE OF TEST :
Host-mediated assay
TEST SYSTEM :
Rodent - mouse Ascites tumor
DOSE/DURATION :
100 mg/kg
REFERENCE :
EKSODD Eksperimental'naya Onkologiya. Experimental Oncology. (V/O Mezhdunarodnaya Kniga, 113095 Mosow, USSR) V.1- 1979- Volume(issue)/page/year: 8(3),70,1986

Precursor & DownStream

Precursor

  • N,N'-Dimethylthiourea
  • 1,3-Dimethylurea
  • 1,1-DIMETHYLUREA
  • 1-Methylurea
  • Sodium nitrite
  • 1,3-dimethyl-1-nitroso-thiourea
  • nitrous acid

DownStream

  • phenylurea
  • TERT-BUTYLUREA
  • Hydrazinecarboxamide,N-methyl-
  • 1-METHYL-3-PHENYLUREA
  • 1-Piperidinecarboxamide
  • 1-ethyl-3-methyl-urea
  • Hydrazinecarboxamide,N-methyl-2-phenyl-
  • 1-benzyl-3-methyl-urea
  • Urea,N-(1-methylethyl)-
  • 3-methyl-1-[2-[2-(methylcarbamoylamino)ethyldisulfanyl]ethyl]urea

Related Compounds

  • Urea,N,N'-dimethyl-N'-(phenylmethyl)-
  • 1,3-dimethyl-1-(4-nitrophenyl)-3-nitrosourea
  • 1-(2-Benzothiazolyl)-1,3-dimethyl-3-nitrosourea
  • Urea,N,N'-diethyl-N'-nitroso-
  • Urea,N,N'-dimethyl-N-phenyl- (9CI)
  • Urea,N,N'-bis(2-fluoroethyl)-N'-nitroso-
  • 4-Biphenylyl Sulfate Potassium Salt
  • (4-(Azepan-1-ylmethyl)phenyl)methanamine 2hcl
  • N-(4-Fluorobenzyl)-N-hydroxy-4-methoxybenzamide
  • N-[3-amino-5-(1,1-dimethylethyl)-2-methoxyphenyl]-2-propanesulfonamide
  • (S)-2-Methyl-N-[(1R)-2,2,2-trifluoro-1-{3-methyl-6-phenylimidazo[2,1-b][1,3]thiazol-2-yl}ethyl]propane-2-sulfinamide
  • 3-Benzyloxy-5-chloro-4-methyl-benzoic acid
  • 1H-Indole-3-acetic acid, I+/--oxo-, 2-propyn-1-yl ester
  • 3-[4-(Pyrrolidin-1-ylmethyl)phenyl]piperidine dihydrochloride
  • 4-Amino-1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)thieno[3,4-d]pyrimidin-2(1H)-one
  • 2-(1-Chloroethyl)-5-(trifluoromethyl)-1,3,4-oxadiazole
The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.