4-Fluorobenzyl isocyanate

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Names

[ CAS No. ]:
132740-43-3

[ Name ]:
4-Fluorobenzyl isocyanate

[Synonym ]:
MFCD00673062
1-fluoro-4-(isocyanatomethyl)benzene

Chemical & Physical Properties

[ Density]:
1.09g/cm3

[ Boiling Point ]:
205ºC at 760mmHg

[ Molecular Formula ]:
C8H6FNO

[ Molecular Weight ]:
151.13800

[ Flash Point ]:
74.7ºC

[ Exact Mass ]:
151.04300

[ PSA ]:
29.43000

[ LogP ]:
1.66150

[ Vapour Pressure ]:
0.256mmHg at 25°C

[ Index of Refraction ]:
n20/D 1.505(lit.)

[ Storage condition ]:
Store under Argon

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H312-H315-H319-H332-H335

[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
R20/21/22

[ Safety Phrases ]:
S26-S36-S37-S39

[ RIDADR ]:
UN 2206 6.1/PG 3

[ WGK Germany ]:
3

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Triphosgene
  • 4-Fluorobenzylamine
  • 4-Fluorophenylacetic acid
  • phosgene
  • 4-Fluorophenylacetyl chloride
  • Diphosgene

DownStream

Articles

Structure-based design of novel boronic acid-based inhibitors of autotaxin.

J. Med. Chem. 54 , 4619-4626, (2011)

Autotaxin (ATX) is a secreted phosphodiesterase that hydrolyzes the abundant phospholipid lysophosphatidylcholine (LPC) to produce lysophosphatidic acid (LPA). The ATX-LPA signaling axis has been impl...

Synthesis and pharmacological in vitro and in vivo profile of 3-oxo-1,1-diphenyl-tetrahydro-oxazolo[3,4-a]pyrazine-7-carboxylic acid 4-fluoro-benzylamide (SHA 68), a selective antagonist of the neuropeptide S receptor.

J. Pharmacol. Exp. Ther. 325(3) , 893-901, (2008)

Neuropeptide S (NPS) has been shown to modulate arousal, sleep wakefulness, anxiety-like behavior, and feeding after central administration of the peptide agonist to mice or rats. We report here the c...


More Articles

Related Compounds

  • 4-Fluorobenzyl chloride-d7
  • 4-Fluorobenzyl chloride-d6
  • 4-Fluorobenzyl bromide
  • 4-fluorobenzyl 6-((3S,4R)-4-(4-amino-5-chloro-2-methoxybenzamido)-3-methoxypiperidin-1-yl)hexanoate
  • 4-fluorobenzyl 2-((3S,4R)-4-(4-amino-5-chloro-2-methoxybenzamido)-3-methoxypiperidin-1-yl)acetate
  • 4-Fluorobenzyl thiocyanate
  • 3-((4-fluorophenyl)sulfonyl)-N-(thiophen-2-ylmethyl)azetidine-1-carboxamide
  • 3-((4-Fluorophenyl)sulfonyl)-1-(phenethylsulfonyl)azetidine
  • 3-(2-(3-((4-methoxyphenyl)sulfonyl)azetidin-1-yl)-2-oxoethyl)-5,6-dimethylpyrimidin-4(3H)-one
  • Benzyl (2-(3-((4-methoxyphenyl)sulfonyl)azetidin-1-yl)-2-oxoethyl)carbamate
  • (3-(Cyclohexylsulfonyl)azetidin-1-yl)(cyclopropyl)methanone
  • 3-(Cyclohexylsulfonyl)-1-((2-phenoxyethyl)sulfonyl)azetidine
  • 1-(3-((furan-2-ylmethyl)sulfonyl)azetidin-1-yl)-2-(1-methyl-1H-indol-3-yl)ethanone
  • 1-((2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)sulfonyl)-3-((furan-2-ylmethyl)sulfonyl)azetidine
  • 4-(3-methoxypyrrolidin-1-yl)-N-(pyridin-3-yl)benzamide
  • N-(3-chloro-4-methoxyphenyl)-4-(3-methoxypyrrolidin-1-yl)benzamide
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