CP-96345

[ Density]:
1.15g/cm3

[ Boiling Point ]:
541.5ºC at 760 mmHg

[ Molecular Formula ]:
C₂₈H₃₂N₂O

[ Molecular Weight ]:
412.57

[ Flash Point ]:
281.3ºC

[ Exact Mass ]:
412.25100

[ PSA ]:
24.50000

[ LogP ]:
5.40850

[ Vapour Pressure ]:
8.65E-12mmHg at 25°C

[ Index of Refraction ]:
1.633

[ Storage condition ]:
-20°C

[ Symbol ]:

GHS07, GHS09

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H315-H319-H335-H400

[ Precautionary Statements ]:
P261-P273-P305 + P351 + P338

[ Hazard Codes ]:
Xi

[ RIDADR ]:
UN 3077 9 / PGIII

Spinal blockage of P/Q- or N-type voltage-gated calcium channels modulates functional and symptomatic changes related to haemorrhagic cystitis in mice.

Br. J. Pharmacol. 172(3) , 924-39, (2015)

Spinal voltage-gated calcium channels (VGCCs) are pivotal regulators of painful and inflammatory alterations, representing attractive therapeutic targets. We examined the effects of epidural administr...

Substance P acts via the neurokinin receptor 1 to elicit bronchoconstriction, oxidative stress, and upregulated ICAM-1 expression after oil smoke exposure.

Am. J. Physiol. Lung Cell. Mol. Physiol. 294(5) , L912-20, (2008)

This study aimed to 1) assess whether substance P (SP) acts via neurokinin (NK)-1 and NK-2 receptors to stimulate neurogenic inflammation (indicated by formation of ICAM-1 expression and oxidative str...

An in vitro model of morphine withdrawal manifests the enhancing effect on human immunodeficiency virus infection of human T lymphocytes through the induction of substance P.

Am. J. Pathol. 169(5) , 1663-70, (2006)

Opioid withdrawal is a crucial and recurring event during the course of opioid abuse that has a negative impact on the immune system. In this study, we investigated whether abrupt withdrawal (AW) or p...

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