NCI 143-447

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Names

[ CAS No. ]:
13292-43-8

[ Name ]:
NCI 143-447

[Synonym ]:
rifaldehyde morpholin-4-ylimine

Chemical & Physical Properties

[ Density]:
1.36g/cm3

[ Molecular Formula ]:
C42H55N3O13

[ Molecular Weight ]:
809.89800

[ Exact Mass ]:
809.37300

[ PSA ]:
226.14000

[ LogP ]:
4.49610

[ Index of Refraction ]:
1.626

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
KD1920675
CHEMICAL NAME :
2,7-(Epoxypentadeca(1,11,13)trienimino)naphtho(2,1-b) furan-1,11(2H)-dione, 5,6,9,17,19,21- hexahydroxy-2,4,12,16,18,20,22-heptamethyl-23-methoxy -8-(N-morpholinoformi midoyl)-, 21-acetate
CAS REGISTRY NUMBER :
13292-43-8
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C42-H55-N3-O13
MOLECULAR WEIGHT :
810.00

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CMTRAG Chemotherapia. (Basel, Switzerland) V.1-12, 1960-67. For publisher information, see CHTHBK. Volume(issue)/page/year: 12,155,1967
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
510 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
38KLAC "Structure-Activity Relationship among the Semisynthetic Antibiotics," Perlman, D., ed., New York, Academic Press, 1977 Volume(issue)/page/year: -,531,1977

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 4-Morpholinamine
  • 3-Formyl Rifamycin

DownStream

Related Compounds

  • nci 143-474
  • NCI 143-473
  • NCI 143-468
  • 9,4-(Epoxypentadeca(1,11,13)trienimino)-1H-benzofuro(5,4-g)indole-10,26(9H)-dione,3-acetyl-5,6,16,18,20-pentahydroxy-14-methoxy-1,2,7,9,15,17,19,21,25-nonamethyl-,16-acetate
  • NCI 143-475
  • 3-Formylrifamycin SV O-propyloxime
  • 3-[(1-Benzothiophen-2-yl)methyl]pyrrolidin-3-ol
  • 1-[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-4-methoxybutanoyl]-4-methoxypyrrolidine-3-carboxylic acid
  • Methyl 3-(1-amino-2,2-difluorocyclopropyl)thiophene-2-carboxylate
  • tert-butyl N-(6-amino-2,2,4-trimethylhexan-3-yl)carbamate
  • tert-butyl N-{2-[4-fluoro-3-(trifluoromethyl)phenyl]-1-oxopropan-2-yl}carbamate
  • 3-Hydroxy-3-(4-methylnaphthalen-1-yl)propanenitrile
  • tert-butyl N-{2-[2-(1-aminocyclopropyl)propan-2-yl]-4-hydroxyphenyl}carbamate
  • 2-{[3-cyclopropyl-4-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)butanamido]methyl}pentanoic acid
  • 3-[3-cyclopropyl-N-ethyl-4-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)butanamido]-2-methylpropanoic acid
  • 3-Chloro-1,1-difluoro-1-phenylpropan-2-one
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