Bisindolylmaleimide I (GF109203X)

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
685.6±55.0 °C at 760 mmHg

[ Melting Point ]:
208-210ºC

[ Molecular Formula ]:
C₂₅H₂₄N₄O₂

[ Molecular Weight ]:
412.484

[ Flash Point ]:
368.5±31.5 °C

[ Exact Mass ]:
412.189911

[ PSA ]:
70.13000

[ LogP ]:
3.88

[ Vapour Pressure ]:
0.0±2.1 mmHg at 25°C

[ Index of Refraction ]:
1.687

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
DMSO: ~1 mg/mlsoluble | Insoluble in water.

Click to get detail MSDS

[ Symbol ]:

GHS07, GHS08

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H351

[ Precautionary Statements ]:
P281

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
R40

[ Safety Phrases ]:
36/37

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
UX9590000

Click to get detail synthetic route

Precursor

DownStream

Tumour suppressor TRIM33 targets nuclear β-catenin degradation.

Nat. Commun. 6 , 6156, (2015)

Aberrant activation of β-catenin in the nucleus has been implicated in a variety of human cancers, but the fate of nuclear β-catenin is unknown. Here we demonstrate that the tripartite motif-containin...

Role of SM22 in the differential regulation of phasic vs. tonic smooth muscle.

Am. J. Physiol. Gastrointest. Liver Physiol. 308(7) , G605-12, (2015)

Preliminary proteomics studies between tonic vs. phasic smooth muscles identified three distinct protein spots identified to be those of transgelin (SM22). The latter was found to be distinctly downre...

Excitation of rat sympathetic neurons via M1 muscarinic receptors independently of Kv7 channels.

Pflugers Arch. 466(12) , 2289-303, (2014)

The slow cholinergic transmission in autonomic ganglia is known to be mediated by an inhibition of Kv7 channels via M1 muscarinic acetylcholine receptors. However, in the present experiments using pri...

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