L(+)-Amethopterin hydrate

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Names

[ CAS No. ]:
133073-73-1

[ Name ]:
L(+)-Amethopterin hydrate

[Synonym ]:
MFCD00150848
L-Amethopterin hydrate
Methotrexate Hydrate

Chemical & Physical Properties

[ Density]:
1.536g/cm3

[ Melting Point ]:
195ºC

[ Molecular Formula ]:
C20H22N8O5

[ Molecular Weight ]:
454.43900

[ Exact Mass ]:
454.17100

[ PSA ]:
210.54000

[ LogP ]:
1.82170

[ Vapour Pressure ]:
0mmHg at 25°C

MSDS

Safety Information

[ Symbol ]:

GHS06, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301-H315-H319-H360

[ Precautionary Statements ]:
P201-P301 + P310-P305 + P351 + P338-P308 + P313

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ Hazard Codes ]:
T

[ Risk Phrases ]:
61-25-36/38

[ Safety Phrases ]:
S26-S45-S53-S36-S37

[ RIDADR ]:
UN 2811 6.1/PG 3

[ WGK Germany ]:
3

[ RTECS ]:
MA1225000

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Standard therapy for acute promyelocytic leukaemia (APL) includes retinoic acid (all-trans retinoic acid (ATRA)), which promotes differentiation of promyelocytic blasts. Although co-administration of ...

Cleavage efficient 2A peptides for high level monoclonal antibody expression in CHO cells.

MAbs 7(2) , 403-12, (2015)

Linking the heavy chain (HC) and light chain (LC) genes required for monoclonal antibodies (mAb) production on a single cassette using 2A peptides allows control of LC and HC ratio and reduces non-exp...

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J. Immunol. 194(4) , 1983-95, (2015)

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