L(+)-Amethopterin hydrate

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Names

[ CAS No. ]:
133073-73-1

[ Name ]:
L(+)-Amethopterin hydrate

[Synonym ]:
MFCD00150848
L-Amethopterin hydrate
Methotrexate Hydrate

Chemical & Physical Properties

[ Density]:
1.536g/cm3

[ Melting Point ]:
195ºC

[ Molecular Formula ]:
C20H22N8O5

[ Molecular Weight ]:
454.43900

[ Exact Mass ]:
454.17100

[ PSA ]:
210.54000

[ LogP ]:
1.82170

[ Vapour Pressure ]:
0mmHg at 25°C

MSDS

Safety Information

[ Symbol ]:

GHS06, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301-H315-H319-H360

[ Precautionary Statements ]:
P201-P301 + P310-P305 + P351 + P338-P308 + P313

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ Hazard Codes ]:
T

[ Risk Phrases ]:
61-25-36/38

[ Safety Phrases ]:
S26-S45-S53-S36-S37

[ RIDADR ]:
UN 2811 6.1/PG 3

[ WGK Germany ]:
3

[ RTECS ]:
MA1225000

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Br. J. Cancer 111(5) , 874-82, (2014)

Standard therapy for acute promyelocytic leukaemia (APL) includes retinoic acid (all-trans retinoic acid (ATRA)), which promotes differentiation of promyelocytic blasts. Although co-administration of ...

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Linking the heavy chain (HC) and light chain (LC) genes required for monoclonal antibodies (mAb) production on a single cassette using 2A peptides allows control of LC and HC ratio and reduces non-exp...

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Intestinal mucositis represents the most common complication of intensive chemotherapy, which has a severe adverse impact on quality of life of cancer patients. However, the precise pathophysiology re...


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Related Compounds

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  • Tert-butyl methyl(5-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-YL)phenyl)pyridin-2-YL)carbamate
  • 4Ttl37aln3
  • M5Hdr29zug
  • (S)-2-(4-Bromo-2-fluoro-5-methylphenyl)pyrrolidine
  • Ethyl (R)-5-(difluoromethyl)-6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazine-2-carboxylate
  • tert-Butyl (3S,4R)-3-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-4-(hydroxymethyl)pyrrolidine-1-carboxylate
  • 2,5-Dioxopyrrolidin-1-yl (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-4-phenylbutanoate
  • Benzyl (2R)-4-cyano-2-methylpiperidine-1-carboxylate
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