Darifenacin

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Names

[ Name ]:
Darifenacin

[Synonym ]:
2-(1-(2-(2,3-Dihydrobenzofuran-5-yl)ethyl)pyrrolidin-3-yl)-2,2-diphenylacetamide
3-Pyrrolidineacetamide, 1-[2-(2,3-dihydro-5-benzofuranyl)ethyl]-α,α-diphenyl-, (3S)-
2-{(3S)-1-[2-(2,3-Dihydro-1-benzofuran-5-yl)ethyl]-3-pyrrolidinyl}-2,2-diphenylacetamide
(S)-1-(2-(2,3-Dihydro-5-benzofuranyl)ethyl)-α,α-diphenyl-3-pyrrolidineacetamide
2-{(3S)-1-[2-(2,3-Dihydro-1-benzofuran-5-yl)ethyl]pyrrolidin-3-yl}-2,2-diphenylacetamide
Darifenacin
(S)-1-(2-(2,3-Dihydro-5-benzofuranyl)ethyl)-a,a-diphenyl-3-pyrrolidineacetamide
2-((3S)-1-(2-(2,3-Dihydro-1-benzofuran-5-yl)ethyl)-3-pyrrolidinyl)-2,2-diphenylacetamide

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
614.3±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₈H₃₀N₂O₂

[ Molecular Weight ]:
426.550

[ Flash Point ]:
325.3±31.5 °C

[ Exact Mass ]:
426.230713

[ PSA ]:
55.56000

[ LogP ]:
4.50

[ Vapour Pressure ]:
0.0±1.8 mmHg at 25°C

[ Index of Refraction ]:
1.624

[ Storage condition ]:
2-8℃

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

(S)-2-{1-[2-(benzofuran-5-yl)ethyl]-3-pyrrolidinyl}-2,2-diphenylacetamide
Darifenacin HBr
5-(2-Bromoethyl)-2,3-dihydrobenzofuran
3-(S)-(1-Carbamoyl-1,1-diphenylmethyl)pyrrolidine
2,2-diphenyl-2-{(S)-1-[2-(2,3-dihydro-benzofuran-5-yl)-ethyl]-pyrrolidin-3-yl}-acetic acid methyl ester
(S)-2,2-diphenyl-2-[1-(tert-butyloxycarbonyl)-3-pyrrolidinyl]acetonitrile
2,2-Diphenyl-2-[(3S)-3-pyrrolidinyl]acetamide
5-Acetyl-2,3-Dihydro-1-Benzofuran
2-bromo-1-(2,3-dihydro-1-benzofuran-5-yl)ethanone