PROSTAGLANDIN A2

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Names

[ Name ]:
PROSTAGLANDIN A2

[Synonym ]:
PROSTAGLANDINS A2
Prostaglandin A
Prosta-5,10,13-trien-1-oic acid, 15-hydroxy-9-oxo-, (5E,13E,15S)-
Prostaglandin A2 solution
(5E,13E,15S)-15-Hydroxy-9-oxoprosta-5,10,13-trien-1-oic acid
Prostaglandin A2
MFCD00077859
PGA2
MEDULLIN

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
515.3±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₀H₃₀O₄

[ Molecular Weight ]:
334.450

[ Flash Point ]:
279.6±26.6 °C

[ Exact Mass ]:
334.214417

[ PSA ]:
74.60000

[ LogP ]:
3.25

[ Vapour Pressure ]:
0.0±3.0 mmHg at 25°C

[ Index of Refraction ]:
1.555

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UK8050000

CHEMICAL NAME :: Prostaglandin A(sup 2)

CAS REGISTRY NUMBER :: 13345-50-1

LAST UPDATED :: 199612

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C20-H30-O4

MOLECULAR WEIGHT :: 334.50

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 93 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 25,460,1973 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 5 mg/kg

SEX/DURATION :: female 16 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetal death

REFERENCE :: PRGLBA Prostaglandins. (Geron-X, Inc., P.O. Box 1108, Los Altos, CA 94022) V.1- 1972- Volume(issue)/page/year: 1,191,1972

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 10 mg/kg

SEX/DURATION :: female 16 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - abortion

REFERENCE :: PRGLBA Prostaglandins. (Geron-X, Inc., P.O. Box 1108, Los Altos, CA 94022) V.1- 1972- Volume(issue)/page/year: 1,191,1972

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 10 mg/kg

SEX/DURATION :: female 16 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetal death

REFERENCE :: PRGLBA Prostaglandins. (Geron-X, Inc., P.O. Box 1108, Los Altos, CA 94022) V.1- 1972- Volume(issue)/page/year: 2,295,1972 *** REVIEWS *** TOXICOLOGY REVIEW CSPEAX Cosmetics and Perfumery. (Oak Park, IL) V.88-90, 1973-75. For publisher information, see CTOIDG. Volume(issue)/page/year: 90(12),28,1975

Safety Information

[ Hazard Codes ]:
F: Flammable;Xi: Irritant;

[ Risk Phrases ]:
R11

[ Safety Phrases ]:
S26

[ RIDADR ]:
UN 1231 3/PG 2

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

Bis(tert-butyldimethylsilyl)-PGE2 oxime
(Z)-7-((1S,2S,3R,5S)-3-((tert-butyldimethylsilyl)oxy)-2-((S,E)-3-((tert-butyldimethylsilyl)oxy)oct-1-en-1-yl)-5-((2-hydroxy-2-methylpropyl)amino)-1-(phenylsulfonyl)cyclopentyl)hept-5-enoic acid
methyl (Z)-7-((1S,2S,3R,5S)-3-((tert-butyldimethylsilyl)oxy)-2-((S,E)-3-((tert-butyldimethylsilyl)oxy)oct-1-en-1-yl)-5-(methylamino)-1-(phenylsulfonyl)cyclopentyl)hept-5-enoate
Methyl (5Z,13E,8R,9S,11R,12S,15S)-11,15-Bis(tert-butyldimethylsiloxy)-9-(methylamino)-8-(phenylsulfonyl)-5,13-prostadienoate
Methyl (5Z,13E,8S,9S,11R,12S,15S)-11,15-Bis(tert-butyldimethylsiloxy)-9-(dimethylamino)-8-(phenylsulfonyl)-5,13-prostadienoate
methyl (E)-7-[1-(benzenesulfonyl)-5-dimethylamino-3-(dimethyl-tert-butyl-silyl)oxy-2-[(E)-3-(dimethyl-tert-butyl-silyl)oxyoct-1-enyl]cyclopentyl]hept-5-enoate
(Z)-7-((1S,2S,3R,E)-3-((tert-butyldimethylsilyl)oxy)-2-((S,E)-3-((tert-butyldimethylsilyl)oxy)oct-1-en-1-yl)-5-(hydroxyimino)-1-(phenylsulfonyl)cyclopentyl)hept-5-enoic acid
(5Z,13E,8R,11R,12S,15S)-11,15-Bis(tert-butyldimethylsiloxy)-9-(anti-oximino)-8-(phenylsulfonyl)-5,13-prostadienoic acid
Methyl (5Z,13E,8R,9S,11R,12S,15S)-11,15-Bis(tert-butyldimethylsiloxy)-9-[[carbo(2',2',2'-trichloroethoxy)]methylamino]-8-(phenylsulfonyl)-5,13-prostadienoate

DownStream

tromethamine
Prostaglandin A2 methyl ester
Prostaglandin F2α methyl ester
Prostaglandin B2

Related Compounds

8-iso Prostaglandin A2
15-acetyl-prostaglandin A2
Prostaglandin A2 methyl ester
19(R)-hydroxy Prostaglandin A2
16,16-dimethyl Prostaglandin A2
prostaglandin A2 isopropyl ester
2-{[3-bromo-5-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)phenyl]formamido}-2-methylpropanoic acid
4-[6-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-4-methylhexanamido]-2-methylbutanoic acid
3-{[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-4,4-difluorobutanamido]methyl}pentanoic acid
2-[5-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-2-methylpentanamido]-4,4-difluorobutanoic acid
2-{2-[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclohexyl]acetamido}-2-methylpropanoic acid
3-{2-[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3,3-dimethylbutanamido]ethoxy}propanoic acid
(2S)-3-cyclopropyl-2-[6-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)hexanamido]propanoic acid
2-[3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-2,2-difluoropropanamido]-2-(thiophen-2-yl)acetic acid
1-[3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-2,2-difluoropropanoyl]-4-methylpiperidine-2-carboxylic acid
3-[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-4,4,4-trifluorobutanamido]-2,2-difluoropropanoic acid

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