PROSTAGLANDIN A2

Suppliers

Names

[ CAS No. ]:
13345-50-1

[ Name ]:
PROSTAGLANDIN A2

[Synonym ]:
PROSTAGLANDINS A2
Prostaglandin A
Prosta-5,10,13-trien-1-oic acid, 15-hydroxy-9-oxo-, (5E,13E,15S)-
Prostaglandin A2 solution
(5E,13E,15S)-15-Hydroxy-9-oxoprosta-5,10,13-trien-1-oic acid
Prostaglandin A2
MFCD00077859
PGA2
MEDULLIN

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
515.3±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C20H30O4

[ Molecular Weight ]:
334.450

[ Flash Point ]:
279.6±26.6 °C

[ Exact Mass ]:
334.214417

[ PSA ]:
74.60000

[ LogP ]:
3.25

[ Vapour Pressure ]:
0.0±3.0 mmHg at 25°C

[ Index of Refraction ]:
1.555

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UK8050000
CHEMICAL NAME :
Prostaglandin A(sup 2)
CAS REGISTRY NUMBER :
13345-50-1
LAST UPDATED :
199612
DATA ITEMS CITED :
5
MOLECULAR FORMULA :
C20-H30-O4
MOLECULAR WEIGHT :
334.50

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
93 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 25,460,1973 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
5 mg/kg
SEX/DURATION :
female 16 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
PRGLBA Prostaglandins. (Geron-X, Inc., P.O. Box 1108, Los Altos, CA 94022) V.1- 1972- Volume(issue)/page/year: 1,191,1972
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
10 mg/kg
SEX/DURATION :
female 16 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - abortion
REFERENCE :
PRGLBA Prostaglandins. (Geron-X, Inc., P.O. Box 1108, Los Altos, CA 94022) V.1- 1972- Volume(issue)/page/year: 1,191,1972
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
10 mg/kg
SEX/DURATION :
female 16 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
PRGLBA Prostaglandins. (Geron-X, Inc., P.O. Box 1108, Los Altos, CA 94022) V.1- 1972- Volume(issue)/page/year: 2,295,1972 *** REVIEWS *** TOXICOLOGY REVIEW CSPEAX Cosmetics and Perfumery. (Oak Park, IL) V.88-90, 1973-75. For publisher information, see CTOIDG. Volume(issue)/page/year: 90(12),28,1975

Safety Information

[ Hazard Codes ]:
F: Flammable;Xi: Irritant;

[ Risk Phrases ]:
R11

[ Safety Phrases ]:
S26

[ RIDADR ]:
UN 1231 3/PG 2

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Bis(tert-butyldimethylsilyl)-PGE2 oxime
  • (Z)-7-((1S,2S,3R,5S)-3-((tert-butyldimethylsilyl)oxy)-2-((S,E)-3-((tert-butyldimethylsilyl)oxy)oct-1-en-1-yl)-5-((2-hydroxy-2-methylpropyl)amino)-1-(phenylsulfonyl)cyclopentyl)hept-5-enoic acid
  • methyl (Z)-7-((1S,2S,3R,5S)-3-((tert-butyldimethylsilyl)oxy)-2-((S,E)-3-((tert-butyldimethylsilyl)oxy)oct-1-en-1-yl)-5-(methylamino)-1-(phenylsulfonyl)cyclopentyl)hept-5-enoate
  • Methyl (5Z,13E,8R,9S,11R,12S,15S)-11,15-Bis(tert-butyldimethylsiloxy)-9-(methylamino)-8-(phenylsulfonyl)-5,13-prostadienoate
  • Methyl (5Z,13E,8S,9S,11R,12S,15S)-11,15-Bis(tert-butyldimethylsiloxy)-9-(dimethylamino)-8-(phenylsulfonyl)-5,13-prostadienoate
  • methyl (E)-7-[1-(benzenesulfonyl)-5-dimethylamino-3-(dimethyl-tert-butyl-silyl)oxy-2-[(E)-3-(dimethyl-tert-butyl-silyl)oxyoct-1-enyl]cyclopentyl]hept-5-enoate
  • (Z)-7-((1S,2S,3R,E)-3-((tert-butyldimethylsilyl)oxy)-2-((S,E)-3-((tert-butyldimethylsilyl)oxy)oct-1-en-1-yl)-5-(hydroxyimino)-1-(phenylsulfonyl)cyclopentyl)hept-5-enoic acid
  • (5Z,13E,8R,11R,12S,15S)-11,15-Bis(tert-butyldimethylsiloxy)-9-(anti-oximino)-8-(phenylsulfonyl)-5,13-prostadienoic acid
  • Methyl (5Z,13E,8R,9S,11R,12S,15S)-11,15-Bis(tert-butyldimethylsiloxy)-9-[[carbo(2',2',2'-trichloroethoxy)]methylamino]-8-(phenylsulfonyl)-5,13-prostadienoate

DownStream

  • tromethamine
  • Prostaglandin A2 methyl ester
  • Prostaglandin F2α methyl ester
  • Prostaglandin B2

Related Compounds

  • 8-iso Prostaglandin A2
  • 15-acetyl-prostaglandin A2
  • Prostaglandin A2 methyl ester
  • 19(R)-hydroxy Prostaglandin A2
  • 16,16-dimethyl Prostaglandin A2
  • prostaglandin A2 isopropyl ester
  • 1-Methyl-1,3,5-triazinan-2-one
  • 2-(3,6-Dichloropyridazin-4-yl)ethan-1-ol
  • tert-Butyl (5-bromo-7-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)methylcarbamate
  • 1-Chloronaphtho[1,2-b]benzofuran
  • 1,4-Bis(3-(4-(7-chloroquinolin-4-yl)piperazin-1-yl)propyl)piperazine
  • 6,7-Difluoro-1-methyl-1,2,3,4-tetrahydroisoquinolinehydrochloride
  • 5,6,7,8-Tetrahydro-8-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-8-quinolinol
  • 3-(4-((Trifluoromethyl)thio)phenyl)acrylaldehyde
  • Benzene, 2-(dibromomethyl)-1,3-difluoro-
  • 2-Amino-2-((S)-1,4-dioxan-2-yl)acetonitrile