Dioxydi-2,2-butanediyl dihydroperoxide

Suppliers

Names

[ Name ]:
Dioxydi-2,2-butanediyl dihydroperoxide

[Synonym ]:
MFCD00042641
dioxydibutane-2,2-diyl dihydroperoxide
kayamekm
ketonox
Hydroperoxide, (dioxybis(1-methylpropylidene))bis-
mepox
mekp
Hi-Point 90 (in DMP)
kayameka
Dioxydi-2,2-butanediyl dihydroperoxide
Methyl ethyl ketone peroxide
permekn
fr222
Hydroperoxide, dioxybis-1-methylpropylidene
EINECS 215-661-2
QOX2&1&OOX2&1&OQ
mekpo
permekg

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
304.9±27.0 °C at 760 mmHg

[ Melting Point ]:
110°C

[ Molecular Formula ]:
C₈H₁₈O₆

[ Molecular Weight ]:
210.225

[ Flash Point ]:
138.2±23.7 °C

[ Exact Mass ]:
210.110336

[ PSA ]:
77.38000

[ LogP ]:
3.65

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.454

[ Water Solubility ]:
0.1-0.5 g/100 mL at 22 ºC

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: EL9450000

CHEMICAL NAME :: 2-Butanone, peroxide

CAS REGISTRY NUMBER :: 1338-23-4

LAST UPDATED :: 199712

DATA ITEMS CITED :: 31

MOLECULAR FORMULA :: C8-H16-O4

MOLECULAR WEIGHT :: 176.24

WISWESSER LINE NOTATION :: 1V2OO2V1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 19,205,1958

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 19,205,1958 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human

DOSE/DURATION :: 480 mg/kg

TOXIC EFFECTS :: Gastrointestinal - changes in structure or function of esophagus Gastrointestinal - nausea or vomiting Gastrointestinal - other changes

REFERENCE :: NCPBBY National Clearinghouse for Poison Control Centers, Bulletin. (U.S. Department of Health, Education, and Welfare, Washington, DC) Volume(issue)/page/year: Jan/Feb,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 484 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 19,205,1958

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 200 ppm/4H

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 19,205,1958

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 65 mg/kg

TOXIC EFFECTS :: Behavioral - muscle weakness Behavioral - ataxia

REFERENCE :: AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 19,205,1958

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 470 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1883- Volume(issue)/page/year: 165,201,1957

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 170 ppm/4H

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 19,205,1958 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2033 mg/kg/7W-I

TOXIC EFFECTS :: Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

REFERENCE :: AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 19,205,1958

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 273 mg/kg/7W-I

TOXIC EFFECTS :: Related to Chronic Data - death

REFERENCE :: AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 19,205,1958 ** TUMORIGENIC DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 282 mg/kg

REFERENCE :: RARSAM Radiation Research, Supplement. (New York, NY) No.1-7, 1959-67. Discontinued. Volume(issue)/page/year: 3,193,1963 *** REVIEWS *** ACGIH TLV-CL 1.5 mg/m3 (0.2 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 0.2 ppm (1.5 mg/m3) JAN 1993 OEL-BELGIUM:STEL 0.2 ppm (1.5 mg/m3) JAN 1993 OEL-DENMARK:STEL 1 mg/m3 JAN 1993 OEL-FINLAND:STEL 0.2 ppm (1.5 mg/m3);Skin JAN 1993 OEL-FRANCE:STEL 0.2 ppm (1.5 mg/m3) JAN 1993 OEL-THE NETHERLANDS:TWA 0.2 ppm (1.5 mg/m3) JAN 1993 OEL-SWEDEN:STEL 0.2 ppm (1.5 mg/m3) JAN 1993 OEL-SWITZERLAND:TWA 0.2 ppm (1.5 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 0.2 ppm (1.5 mg/m3);STEL 0.2 ppm JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO METHYL ETHYL KETONE PEROXIDE-air:CL 0.2 ppm REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80105 No. of Facilities: 2226 (estimated) No. of Industries: 29 No. of Occupations: 31 No. of Employees: 20053 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80105 No. of Facilities: 1879 (estimated) No. of Industries: 23 No. of Occupations: 31 No. of Employees: 25827 (estimated) No. of Female Employees: 6514 (estimated)

Safety Information

[ Symbol ]:

GHS02, GHS05

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H242-H314

[ Precautionary Statements ]:
P220-P280-P305 + P351 + P338-P310-P410-P411 + P235

[ Personal Protective Equipment ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
O:Oxidizingagent;C:Corrosive;

[ Risk Phrases ]:
R7;R22;R34

[ Safety Phrases ]:
S17-S26-S36/37/39-S45-S14-S53-S3/7-S47-S7

[ RIDADR ]:
UN 3105 5.2

[ WGK Germany ]:
1

[ Packaging Group ]:
II

[ Hazard Class ]:
5.2

[ HS Code ]:
2909600000

Customs

[ HS Code ]: 2909600000

[ Summary ]:
2909600000 alcohol peroxides, ether peroxides, ketone peroxides and their halogenated, sulphonated, nitrated or nitrosated derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

Articles

[Chemical burns of the upper digestive tract and cytolytic hepatitis following ingestion of a mixture of methyl ethyl ketone peroxide, diacetone alcohol and diisobutyl phthalate].

J. Toxicol. Clin. Exp. 12(4-5) , 205-6, (1992)

Effect of dietary vitamin E on methyl ethyl ketone peroxide damage to microsomal cytochrome P-450 peroxidase.

Chem. Biol. Interact. 55(3) , 317-26, (1985)

The effect of dietary vitamin E on in vivo and in vitro damage by methyl ethyl ketone peroxide (MEKP) to cytochrome P-450 and its associated enzymatic activity was studied. In vivo, MEKP damaged micro...

Contact sensitivity to methyl ethyl ketone peroxide in a paint sprayer.

Contact Dermatitis 26(1) , 52-3, (1992)

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