Hydroxocobalamin

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Names

[ CAS No. ]:
13422-51-0

[ Name ]:
Hydroxocobalamin

[Synonym ]:
Hydroxocobalamin
Vitamin B12a acetate
EINECS 236-533-2
hydroxycobalamin
ohb12
vitamin B12a
duradoce
cobalex
docevita
MFCD00082532
docclan
hydroxycobalamine
docelan
vibeden
hydrovit
axlon
axion

Chemical & Physical Properties

[ Melting Point ]:
200ºC (decomposes)

[ Molecular Formula ]:
C62H89CoN13O15P

[ Molecular Weight ]:
1346.36

[ Exact Mass ]:
1345.567017

[ PSA ]:
484.10000

[ LogP ]:
6.43870

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
methanol: 10 mg/mL at 20 °C, clear, dark red

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
GG3820000
CHEMICAL NAME :
Cobinamide, dihydroxide, dihydrogen phosphate (ester), mono (inner salt), 3'- ester with 5,6- dimethyl-1-alpha-D-ribofuranosylbenzimidazole
CAS REGISTRY NUMBER :
13422-51-0
LAST UPDATED :
199701
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C62-H89-Co-N13-O15-P

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>50 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,867,1990 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3794 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 8 No. of Employees: 3157 (estimated) No. of Female Employees: 1154 (estimated)

Safety Information

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
GG3820000

Precursor & DownStream

Precursor

DownStream

  • (trifluoromethyl)cobalamine

Articles

Pseudo-blood leak? A hemodialysis mystery.

Clin. Nephrol. 79(4) , 323-5, (2013)

Hydroxocobalamin is a treatment for cyanide toxicity with few side effects. We report a case of a hemodialysis patient whose treatment was compromised by hydroxocobalamin interference with the blood l...

A patient with an inborn error of vitamin B12 metabolism (cblF) detected by newborn screening.

Pediatrics 132(1) , e257-61, (2013)

A neonate, who was found to have an elevated C3/C2 ratio and minimally elevated propionylcarnitine on newborn screening, was subsequently identified as having the rare cblF inborn error of vitamin B12...

Severe combined immunodeficiency resulting from mutations in MTHFD1.

Pediatrics 131(2) , e629-34, (2013)

Folate and vitamin B(12) metabolism are essential for de novo purine synthesis, and several defects in these pathways have been associated with immunodeficiency. Here we describe the occurrence of sev...


More Articles

Related Compounds

  • hydroxocobalamin
  • Hydroxocobalamin Acetate
  • HYDROXOCOBALAMIN HYDROCHLORIDE
  • hydroxocobalamin hydrochloride
  • hydroxocobalamin hydrochloride
  • hydroxocobalamin hydrochloride
  • 1-(6-Chloropyridin-3-YL)-2-methylpropan-2-amine
  • 1-(6-Bromopyridin-3-YL)-2-methylpropan-2-amine
  • 1-(2-Bromopyridin-4-YL)-2-methylpropan-2-amine
  • methyl 2-{[(4-phenyltetrahydro-2H-pyran-4-yl)carbonyl]amino}-5-(propan-2-yl)-1,3-thiazole-4-carboxylate
  • 1-(2-Chloropyrimidin-5-YL)-2-methylpropan-2-amine
  • 3-Fluoro-5,6,7,8-tetrahydro-1,8-naphthyridine-4-carboxylic acid
  • 3-Methoxy-6,7,8,9-tetrahydro-5H-pyrido[3,4-C]azepine
  • 1-Chloro-6,7,8,9-tetrahydro-5H-pyrido[4,3-C]azepine
  • 3-(Chloromethyl)-5-iodobenzonitrile
  • N-(3-(Chloromethyl)-5-nitrophenyl)acetamide
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