N-(Trimethylsilyl)acetamide

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Names

[ CAS No. ]:
13435-12-6

[ Name ]:
N-(Trimethylsilyl)acetamide

[Synonym ]:
EINECS 236-565-7
N-Trimethylsilylacetamide,TMS acetamide
N-(Trimethylsilyl)acetamide
N-Trimethylsilylacetamide
MFCD00008671
N-TMS-acetamide
Acetamide, N-(trimethylsilyl)-

Chemical & Physical Properties

[ Density]:
0.9±0.1 g/cm3

[ Boiling Point ]:
190.2±0.0 °C at 760 mmHg

[ Melting Point ]:
46-49 °C(lit.)

[ Molecular Formula ]:
C5H13NOSi

[ Molecular Weight ]:
131.248

[ Flash Point ]:
57.2±0.0 °C

[ Exact Mass ]:
131.076645

[ PSA ]:
29.10000

[ LogP ]:
0.60

[ Vapour Pressure ]:
0.5±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.406

[ Storage condition ]:
Flammables area

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AD0250000
CHEMICAL NAME :
Acetamide, N-(trimethylsilyl)-
CAS REGISTRY NUMBER :
13435-12-6
BEILSTEIN REFERENCE NO. :
0741928
LAST UPDATED :
199701
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C5-H13-N-O-Si
MOLECULAR WEIGHT :
131.28
WISWESSER LINE NOTATION :
1VM-SI-1&1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
350 mg/kg
TOXIC EFFECTS :
Immunological Including Allergic - decreased immune response
REFERENCE :
StoGD# Personal Communication from G.D. Stoner, Dept. of Community Medicine, School of Medicine, Univ. of California, La Jolla, CA 92037, May 25, 1975 Volume(issue)/page/year: 27MAY1975

Safety Information

[ Hazard Codes ]:
F:Flammable;Xi:Irritant;

[ Risk Phrases ]:
R11;R36/37/38

[ Safety Phrases ]:
S37/39-S26

[ RIDADR ]:
1325

[ WGK Germany ]:
3

[ RTECS ]:
AD0250000

[ Packaging Group ]:
III

[ Hazard Class ]:
4.1

[ HS Code ]:
2931900090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Acetamide
  • Hexamethyldisilazane
  • 3-O-benzyl-1,2-di-O-acetyl-5-O-(methylsulfonyl)-4-C-(methylsulfonyloxymethyl)-α,β-L-threo-pentofuranose
  • 3-Methyl-2-butanone
  • N,O-Bis(trimethylsilyl)acetamide
  • Pinacolone
  • 2-Methyl-3-pentanone
  • 3-Pentanone
  • Acetyl chloride

DownStream

  • N-benzyl-3-chloro-2-trimethylsilyloxypropan-1-amine
  • [bis(chloromethyl)phosphoryloxy-(chloromethyl)phosphoryl]-chloromethane
  • Allylisopropylacetamide
  • n-Hexanamide
  • Trimethylsilyl acetate
  • diacetamide
  • 1,3,2-benzodioxaphosphol-2-yloxy(trimethyl)silane
  • N-(1,3,2-benzodioxaphosphol-2-yl)acetamide
  • 3-Phenylpropanamide
  • N,O-Bis(trimethylsilyl)acetamide

Customs

[ HS Code ]: 2931900090

[ Summary ]:
2931900090. other organo-inorganic compounds. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tariff:6.5%. General tariff:30.0%

Articles

M.Vecchi and K.Kaiser

J. Chromatogr. A. 26 , 22, (1967)

D.R. Knapp

Handbook of Analytical Derivatization Reactions , (1979), 572

Quantitative analysis of ascorbic acid in tissues by gas-liquid chromatography.

Anal. Biochem. 43 , 401, (1971)


More Articles

Related Compounds

  • N-Benzyl-N-(trimethylsilyl)acetamide
  • N-Methyl-N-(trimethylsilyl)acetamide
  • N-Acetoxy-N-(trimethylsilyl)acetamide
  • N-(o-chlorobenzyl)-N-(trimethylsilyl)acetamide
  • 2,2,2-Trifluoro-N-methyl-N-(trimethylsilyl)acetamide
  • N-trimethylsilyl-N-(2-trimethylsilyloxypyrimidin-4-yl)acetamide
  • 3,4,5-trimethoxy-N-(2-(5-(3-nitrobenzyl)-4-oxo-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)benzamide
  • 4-fluoro-N-(2-(5-(3-nitrobenzyl)-4-oxo-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)benzamide
  • Methyl 3-[(2-chloro-1-oxopropyl)amino]benzoate
  • 3,4-difluoro-N-(2-(5-(3-nitrobenzyl)-4-oxo-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)benzamide
  • N-(2-methoxyphenyl)-12-oxo-6,7,8,9,10,12-hexahydroazepino[2,1-b]quinazoline-3-carboxamide
  • 4-(5-(Furan-2-yl)-1,2,4-oxadiazol-3-yl)-1-phenylpyrrolidin-2-one
  • 1-Phenyl-4-(5-(thiophen-2-ylmethyl)-1,2,4-oxadiazol-3-yl)pyrrolidin-2-one
  • 1-Phenyl-4-(5-pyridin-4-yl-1,2,4-oxadiazol-3-yl)pyrrolidin-2-one
  • N-(2-(5-(3-nitrobenzyl)-4-oxo-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)-4-(trifluoromethyl)benzamide
  • (Z)-3-(benzo[d][1,3]dioxol-5-yl)-N-(2-(5-(3-nitrobenzyl)-4-oxo-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)acrylamide
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