2-Aminopyridine-3-carboxamide

Names

[ CAS No. ]:
13438-65-8

[ Name ]:
2-Aminopyridine-3-carboxamide

[Synonym ]:
2-Aminonicotinamide

Chemical & Physical Properties

[ Density]:
1.323g/cm3

[ Boiling Point ]:
328.2ºC at 760mmHg

[ Melting Point ]:
194-200℃

[ Molecular Formula ]:
C₆H₇N₃O

[ Molecular Weight ]:
137.13900

[ Flash Point ]:
152.3ºC

[ Exact Mass ]:
137.05900

[ PSA ]:
82.00000

[ LogP ]:
1.04420

[ Appearance of Characters ]:
Solid | Pale yellow

[ Vapour Pressure ]:
0.000192mmHg at 25°C

[ Index of Refraction ]:
1.643

MSDS

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301-H317-H319

[ Precautionary Statements ]:
P280-P301 + P310-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
22-36-43

[ Safety Phrases ]:
26-36/37

[ RIDADR ]:
UN 2811 6.1 / PGIII

[ HS Code ]:
2933399090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

2-Aminonicotinic acid
Ethyl 2-aminonicotinate
Nicotinamide
2-aminonicotinonitrile
malonaldehyde
3-Amino-3-iminopropanamide hydrochloride (1:1)
2-Chloro-3-cyanopyridine
Nicotinamide N-oxide
Methyl 2-aminonicotinate
1,3,3-Triethoxy-1-propene

DownStream

Customs

[ HS Code ]: 2933399090

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Modulation of the pentose phosphate pathway alters phase I metabolism of testosterone and dextromethorphan in HepG2 cells.

Acta Pharmacol. Sin. 36(2) , 259-67, (2015)

The pentose phosphate pathway (PPP) is involved in the activity of glucose-6-phosphate dehydrogenase (G6PD) and generation of NADPH, which plays a key role in drug metabolism. The aim of this study wa...