Afugan

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Names

[ Name ]:
Afugan

[Synonym ]:
2-(Diethoxy-thiophosphoryloxy)-5-methyl-pyrazolo[1,5-a]pyrimidine-6-carboxylic acid ethyl ester
Ethyl 2-[(diethoxyphosphorothioyl)oxy]-5-methylpyrazolo[1,5-a]pyrimidine-6-carboxylate
ethyl 2-diethoxyphosphinothioyloxy-5-methylpyrazolo[1,5-a]pyrimidine-6-carboxylate
Pyrazolo[1,5-a]pyrimidine-6-carboxylic acid, 2-[(diethoxyphosphinothioyl)oxy]-5-methyl-, ethyl ester
ethyl 2-[(diethoxyphosphinothioyl)oxy]-5-methylpyrazolo[1,5-a]pyrimidine-6-carboxylate
2-Hydroxy-5-methylpyrazolo[1,5-a]pyrimidine-6-carboxylic Acid Ethyl Ester O-Ester with O,O-Diethyl Phosphorthioate
PYRAZOPHOS
EINECS 236-656-1
Curamil
MFCD00055494
O-6-ethoxycarbonyl-5-methylpyrazolo[1,5-a]pyrimidin-2-yl O,O-diethyl phosphorothioate
Afugan
2-[(Diethoxyphosphinothioyl)oxy]-5-methylpyrazolo[1,5-a]pyrimidine-6-carboxylic Acid Ethyl Ester

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Melting Point ]:
51℃

[ Molecular Formula ]:
C₁₄H₂₀N₃O₅PS

[ Molecular Weight ]:
373.365

[ Exact Mass ]:
373.086121

[ PSA ]:
126.08000

[ LogP ]:
3.01

[ Index of Refraction ]:
1.596

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TF2035000

CHEMICAL NAME :: Phosphorothioic acid, O,O-diethyl ester, O-ester with (6-ethoxycarbonyl-5-methyl) pyrazolo(1,5-a)pyrimidin-2-ol

CAS REGISTRY NUMBER :: 13457-18-6

LAST UPDATED :: 199612

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C14-H20-N3-O5-P-S

MOLECULAR WEIGHT :: 373.40

WISWESSER LINE NOTATION :: T56 ANN FNJ COPS&O2&O2 G1 HVO2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 218 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: KHZDAN Khigiena i Zdraveopazvane. Hygiene and Sanitation. (Hemus, Blvd. Russki 6, Sofia, Bulgaria) V.9- 1966- Volume(issue)/page/year: 23,538,1980

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,734,1991

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 435 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85KYAH "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989 Volume(issue)/page/year: 11,1266,1989

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - quail

DOSE/DURATION :: 118 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,734,1991

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 184 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85KYAH "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989 Volume(issue)/page/year: 11,1266,1989 *** REVIEWS *** TOXICOLOGY REVIEW RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962- Volume(issue)/page/year: 53,99,1974

Safety Information

[ Symbol ]:

GHS06, GHS09

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301-H332-H410

[ Precautionary Statements ]:
P273-P301 + P310-P501

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ Hazard Codes ]:
Xn: Harmful;N: Dangerous for the environment;

[ Risk Phrases ]:
20/22-50/53

[ Safety Phrases ]:
36/37-46-60-61

[ RIDADR ]:
UN 2783

[ RTECS ]:
TF2035000

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1(b)

Articles

[Biochemical changes in the myocardium in experimental chronic pirazofos poisoning].

Probl. Khig. 10 , 52-8, (1985)

The authors investigate the 12 month effect of the organophosphorus pesticide "Pyrazophos", in the myocardium status of albino male rats treated per os by 1/20, 1/100, and 1/200 LD50 of the preparatio...

Removal of pyrazophos from treated fabric using household laundering.

Bull. Environ. Contam. Toxicol. 42(5) , 687-90, (1989)

Pesticide residues in artichokes: effect of different head shape.

J. Environ. Sci. Health B 31(6) , 1189-99, (1996)

Residues of three pesticides (dimethoate, parathion, and pyrazophos) in two artichoke cultivars, Masedu and Spinoso sardo, were investigated. The amount of pesticides in artichokes was greatly affecte...

2-bromo-5-(3-bromopropoxy)-1,3-dimethyl-benzene
3-(4-Bromo-5-methylthiophen-2-yl)-3-methylbutanoic acid
3-(4-Bromo-5-methylthiophen-2-yl)-3-methylbutan-1-amine
3-(4-Bromo-5-chlorothiophen-2-yl)-3-methylbutan-1-amine
Hydrazine, [1-(2-benzofuranyl)-2-(methylthio)ethyl]-
(1R)-1-(4-bromo-5-methylthiophen-2-yl)ethan-1-amine
(1S)-1-(4-bromo-5-chlorothiophen-2-yl)ethan-1-amine
(1R)-1-(4-bromo-5-chlorothiophen-2-yl)ethan-1-amine
(1S)-1-(4-bromo-5-methylthiophen-2-yl)ethan-1-ol
(1R)-1-(4-bromo-5-methylthiophen-2-yl)ethan-1-ol

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