Iso-FK-506 (iso-Tacrolimus)

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Names

[ Name ]:
Iso-FK-506 (iso-Tacrolimus)

[Synonym ]:
[3S-[3R*[1R*,2R*,4(1S*,3S*,4S*)],6S*,10R*,12R*,13R*,14R*,16S*,17S*,24aR*]]-6,9,10,11,12,13,14,15,16,17,22,23,24,24a-tetradecahydro-17-hydroxy-3-[2-hydroxy-4-(4-hydroxy-3-methoxycyclohexyl)-1,3-dimethyl-3-butenyl]-12,14-dimethoxy-8,10,16-trimethyl-6-(2-propenyl)-13,17-epoxy-3H-pyrido[2,1-c][1,4]oxaazacycloheneicosine-1,5,18,19(4H,21H)-tetrone

Chemical & Physical Properties

[ Molecular Formula ]:
C₄₄H₆₉NO₁₂

[ Molecular Weight ]:
804.01800

[ Exact Mass ]:
803.48200

[ PSA ]:
178.36000

[ LogP ]:
4.57690

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

33-O-tert.butyldimethylsilyl-26-O-trimethylsilyl-iso-FK-50
Tacrolimus
33-O-tert.butyldimethylsilyl-FK-506
5-Hydroxy-33-tert-butyldimethylsilyloxy-iso-FK-506
22-Hydroxy-33-O-tert-butyldimethylsilyloxy-27-O-triMethylsilyl-iso-FK-506
33-O-tert-butyldimethylsilyl-22(S)-dihydro-FK-506