nips hcl

Names

[ CAS No. ]:
135261-88-0

[ Name ]:
nips hcl

[Synonym ]:
N-(4-isothiocyanatophenethyl)spiperone

Chemical & Physical Properties

[ Density]:
1.22g/cm3

[ Boiling Point ]:
754.7ºC at 760mmHg

[ Molecular Formula ]:
C32H34ClFN4O2S

[ Molecular Weight ]:
593.15400

[ Flash Point ]:
410.2ºC

[ Exact Mass ]:
592.20800

[ PSA ]:
88.31000

[ LogP ]:
6.64930

[ Vapour Pressure ]:
1.15E-22mmHg at 25°C

[ Index of Refraction ]:
1.632

Safety Information

Articles

Prolonged D2 antidopaminergic activity of alkylating and nonalkylating derivatives of spiperone in rat brain.

Mol. Pharmacol. 42 , 856-863, (1992)

Alkyl and arylalkyl derivatives of the dopamine (DA) D2 antagonist spiperone were prepared and characterized chemically and pharmacologically. They included the N-methyl, N-phenethyl (NPS), and N-p-am...

N-(p-isothiocyanatophenethyl)spiperone, a selective and irreversible antagonist of D2 dopamine receptors in brain.

J. Pharmacol. Exp. Ther. 257 , 608-615, (1991)

N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ), an irreversible and nonselective protein-modifying reagent, has been used extensively in studies involving inactivation of receptors. Here, we pr...

Modulation of [(35)S]GTPgammaS binding to chinese hamster ovary cell membranes by D(2(short)) dopamine receptors.

Neurosci. Lett. 280(2) , 135-8, (2000)

Rat dopamine D(2short) expressed in Chinese hamster ovary (CHO) cells were characterized by means of activation of [(35)S]-guanosine 5'-O-(gamma-thiotriphosphate) ([(35)S]GTPgammaS) binding and inhibi...


More Articles

Related Compounds

  • Difelikefalin HCl
  • EPZ020411 HCl
  • Pazopanib HCl (GW786034 HCl)
  • OCTENIDINE HCl
  • GSK269962 HCl
  • ALAPROCLATE HCL
  • 3-(5-Phenyl-1,3,4-oxadiazol-2-yl)morpholine hydrochloride
  • [1-(1,2,4-Oxadiazol-3-ylmethyl)piperidin-3-yl]methanamine dihydrochloride
  • (piperidin-2-yl)methyl N-butylcarbamate hydrochloride
  • piperidin-2-ylmethyl N-ethylcarbamate hydrochloride
  • [3-Amino-2-(4-chlorophenyl)propyl]dimethylamine dihydrochloride
  • 4-(piperidin-4-yl)-4H-1,2,4-triazol-3-amine dihydrochloride
  • Sodium 2-(4-methyl-1,3-thiazol-2-yl)propanoate
  • 2-{2-[(2,2,2-Trifluoroethyl)amino]acetamido}pent-4-enoic acid hydrochloride
  • 5-(Methanesulfonylmethyl)-2-methoxyaniline hydrochloride
  • 4-[Fluoro(2-fluorophenyl)methyl]piperidine hydrochloride
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