4-chloronaphthalene-1,8-dicarboxylic acid

Names

[ CAS No. ]:
13577-46-3

[ Name ]:
4-chloronaphthalene-1,8-dicarboxylic acid

[Synonym ]:
1,8-Naphthalenedicarboxylic acid,4-chloro
Naphthalic acid,4-chloro
4-chloro-naphthalene-1,8-dicarboxylic acid
4-Chlor-naphthalin-1,8-dicarbonsaeure
4-Chlornaphthalsaeure
4-Chloro-1,8-naphthalenedicarboxylic acid
4-Chlornapthylsaeure
4-Chloronaphthalic acid

Chemical & Physical Properties

[ Density]:
1.56g/cm3

[ Boiling Point ]:
535.8ºC at 760 mmHg

[ Molecular Formula ]:
C12H7ClO4

[ Molecular Weight ]:
250.63500

[ Flash Point ]:
277.8ºC

[ Exact Mass ]:
250.00300

[ PSA ]:
74.60000

[ LogP ]:
2.88960

[ Vapour Pressure ]:
2.6E-12mmHg at 25°C

[ Index of Refraction ]:
1.711

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
QJ3434700
CHEMICAL NAME :
1,8-Naphthalenedicarboxylic acid, 4-chloro-
CAS REGISTRY NUMBER :
13577-46-3
BEILSTEIN REFERENCE NO. :
2054783
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C12-H7-Cl-O4

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
3500 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Behavioral - muscle weakness Gastrointestinal - other changes
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 33(10),57,1989
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
4980 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Behavioral - muscle weakness Gastrointestinal - other changes
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 33(10),57,1989

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Acenaphthylene, 5-chloro-1,2-dihydro- (9CI)
  • 5-Chloracenaphthylenglykol
  • 5-chloroacenaphthylene
  • Acenaphthene
  • acetic acid
  • Acetone

DownStream

  • 4-Chloro-1,8-naphthalic anhydride

Related Compounds

  • 4-chloronaphthalene-1,8-dicarboxylic acid anhydride
  • 4-acetylnaphthalene-1,8-dicarboxylic acid
  • 4-ethylnaphthalene-1,8-dicarboxylic acid
  • 4-fluoronaphthalene-1,8-dicarboxylic acid
  • 4,5-dibromonaphthalene-1,8-dicarboxylic acid
  • 4-benzoyl-naphthalene-1,8-dicarboxylic acid
  • 3-(5-Chloro-2-methanesulfonylpyrimidin-4-yl)-3-oxo-2-(4-oxo-3,4-dihydroquinazolin-2-yl)propanenitrile
  • N-(5-ethylsulfanyl-1,3,4-thiadiazol-2-yl)-2-[(4-oxo-1-phenyl-2H-pyrazolo[3,4-d]pyrimidin-6-yl)sulfanyl]acetamide
  • 1-(3,4-dihydroisoquinolin-2(1H)-yl)-2-[(4-hydroxy-6-propylpyrimidin-2-yl)sulfanyl]ethanone
  • N-(4-amino-2-((2-((4-ethoxyphenyl)amino)-2-oxoethyl)thio)-6-oxo-1,6-dihydropyrimidin-5-yl)furan-2-carboxamide
  • N-(3-chlorophenyl)-2-[(6-oxo-4-phenyl-1,6-dihydropyrimidin-2-yl)thio]acetamide
  • N-benzyl-2-[(4-oxo-6-phenyl-1H-pyrimidin-2-yl)sulfanyl]acetamide
  • 2-[(4-Chloro-2-methylphenyl)amino]-4(3H)-quinazolinone
  • 3-Bromo-2-chloro-N-Fmoc-L-phenylalanine
  • N-(3-chloro-4-fluorophenyl)-4-oxo-2-(phenylamino)-5,6-dihydro-4H-1,3-thiazine-6-carboxamide
  • 4-[7,8-Bis(methyloxy)-3h-pyrazolo[3,4-c]isoquinolin-5-yl]phenol
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