Big endothelin-1 (rat 1-39)

Names

[ CAS No. ]:
135842-15-8

[ Name ]:
Big endothelin-1 (rat 1-39)

[Synonym ]:
CYS-SER-CYS-SER-SER-LEU-MET-ASP-LYS-GLU-CYS-VAL-TYR-PHE-CYS-HIS-LEU-ASP-ILE-ILE-TRP-VAL-ASN-THR-PRO-GLU-ARG-VAL-VAL-PRO-TYR-GLY-LEU-GLY-SER-PRO-SER-ARG-SER

Chemical & Physical Properties

[ Molecular Formula ]:
C192H292N50O58S5

[ Molecular Weight ]:
4389

[ Storage condition ]:
−20°C

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

Articles

Chronic endothelin receptor blockade attenuates progressive ventricular dilation and improves cardiac function in rats with myocardial infarction: possible involvement of myocardial endothelin system in ventricular remodeling.

Circulation 96(11) , 3963-73, (1997)

Left ventricular dilatation after myocardial infarction is associated with impaired ventricular function and heart failure and has important implications for survival. The purpose of this study was to...

Phosphoramidon blocks the pressor activity of porcine big endothelin-1-(1-39) in vivo and conversion of big endothelin-1-(1-39) to endothelin-1-(1-21) in vitro.

Proc. Natl. Acad. Sci. U. S. A. 88(3) , 703-7, (1991)

In porcine aortic endothelial cells, the 21-amino acid peptide endothelin-1 (ET-1) is formed from a 39-amino acid intermediate called "big endothelin-1" (big ET-1) by a putative ET-converting enzyme (...

Phosphoramidon blocks big-endothelin-1 but not endothelin-1 enhancement of vascular permeability in the rat.

Br. J. Pharmacol. 107(4) , 996-1000, (1992)

1. Changes in vascular permeability following intravenous injections of human big-endothelin-1 (big-ET-1) and endothelin-1 (ET-1) were measured by extravasation of Evans blue dye (EB, 20 mg kg-1) in s...


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Related Compounds

  • 2-(3-bromo-1-methyl-1H-pyrazol-5-yl)-2-methylpropan-1-amine
  • 4-(2-Fluoro-4-methoxyphenyl)-2-methylbutan-2-amine
  • (2S)-1-(1-ethyl-2,3-dihydro-1H-indol-5-yl)propan-2-ol
  • 2-[4-(Difluoromethoxy)-2-fluorophenyl]propan-2-amine
  • tert-butyl N-{2-hydroxy-3-[(2-oxo-1,2,3,4-tetrahydroquinolin-6-yl)oxy]propyl}carbamate
  • 1-[1-(2-methylpropyl)-1H-pyrazol-4-yl]cyclobutane-1-carboxylic acid
  • 2-(3-Amino-2,2-dimethylcyclopropyl)-6-bromophenol
  • tert-butyl N-[2-(1-hydroxypropan-2-yl)-2,3-dihydro-1H-isoindol-4-yl]carbamate
  • [4,4-difluoro-1-(1H-pyrrol-2-yl)cyclohexyl]methanamine
  • 1-amino-3-[5-chloro-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]propan-2-ol
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