Alprenolol

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Names

[ CAS No. ]:
13655-52-2

[ Name ]:
Alprenolol

[Synonym ]:
Alpheprol
Alprenolol
ALLPRENOLOL

Chemical & Physical Properties

[ Density]:
1.007g/cm3

[ Boiling Point ]:
383.4ºC at 760mmHg

[ Melting Point ]:
57.5°C

[ Molecular Formula ]:
C₁₅H₂₃NO₂

[ Molecular Weight ]:
249.34900

[ Flash Point ]:
185.7ºC

[ Exact Mass ]:
249.17300

[ PSA ]:
41.49000

[ LogP ]:
2.54370

[ Vapour Pressure ]:
1.46E-06mmHg at 25°C

[ Index of Refraction ]:
1.5250 (estimate)

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UA5350000

CHEMICAL NAME :: 2-Propanol, 1-(o-allylphenoxy)-3-(isopropylamino)-

CAS REGISTRY NUMBER :: 13655-52-2

LAST UPDATED :: 199606

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C15-H23-N-O2

MOLECULAR WEIGHT :: 249.39

WISWESSER LINE NOTATION :: 1Y1&M1YQ1OR B2U1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 210 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: UGLAAD Ugeskrift for Laeger. Doctor's Weekly. (Almindelige Danske Laegeforening, Esplanaden 8C4, 1045 Copenhagen K, Denmark) V.1- 1839- Volume(issue)/page/year: 139,2817,1977

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 90 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique. (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France) V.9- 1974- Volume(issue)/page/year: 18,151,1983

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 20 mg/kg

TOXIC EFFECTS :: Autonomic Nervous System - sympathomimetic

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,1022,1977

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 184 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 8,137,1974

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 102 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 8,137,1974

Safety Information

[ Hazard Codes ]:
T: Toxic;

[ Risk Phrases ]:
R23/24/25

[ Safety Phrases ]:
36/37/39-45

[ RIDADR ]:
UN 3249

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1(b)

Synthetic Route

Click to get detail synthetic route

Related Compounds

p-Alprenolol
Alprenolol-HCl
(+)-alprenolol
[3H]-Alprenolol
dansyl alprenolol
Alprenolol benzoate
(1-(Pyridin-2-ylmethyl)pyrrolidin-2-yl)methanamine hydrochloride
(1-(Pyridin-3-ylmethyl)pyrrolidin-2-yl)methanamine hydrochloride
(1-((2-Bromopyridin-4-yl)methyl)pyrrolidin-2-yl)methanamine hydrochloride
C-[1-(2-Chloro-pyrimidin-4-ylmethyl)-pyrrolidin-2-yl]-methylamine hydrochloride
(1-(Thiazol-5-ylmethyl)pyrrolidin-2-yl)methanamine hydrochloride
(1-((3-Chloropyrazin-2-yl)methyl)pyrrolidin-2-yl)methanamine hydrochloride
(1-((5-Bromothiophen-2-yl)sulfonyl)pyrrolidin-2-yl)methanamine hydrochloride
(1-(Thiophen-2-ylsulfonyl)pyrrolidin-2-yl)methanamine hydrochloride
(3-(Aminomethyl)pyrrolidin-1-yl)(2,3-dihydrobenzo[b][1,4]dioxin-5-yl)methanone hydrochloride
(3-(Aminomethyl)pyrrolidin-1-yl)(2-chloropyridin-3-yl)methanone hydrochloride

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